Opentargets

Target Known Drugs

target_known_drugs

Read-onlyIdempotent

"What drugs target [gene]" / "approved drugs against [target]" / "clinical-trial drugs for [gene]" — drugs that have been clinically tested or approved against a drug target (Ensembl gene ID). Returns drug names, mechanisms, indications, clinical trial phases. Use for competitive landscape / drug-repositioning queries.

Input Schema

TableJSON Schema

Name	Required	Description	Default
`size`	No	1-100 (default 25)
`ensembl_id`	Yes

Output Schema

TableJSON Schema

Name	Required	Description	Default
`target`	No

Schema Changelog

Changes observed during successful MCP inspections.

Changed2 schema fields changedOct 11, 2026

removedOutput schema / properties / data

Removed value: -{
-  "properties": {
-    "target": {
-      "properties": {
-        "approvedSymbol": {
-          "description": "Target symbol",
-          "type": "string"
-        },
-        "id": {
-          "description": "Target ID",
-          "type": "string"
-        },
-        "knownDrugs": {
-          "properties": {
-            "count": {
-              "description": "Total known drugs",
-              "type": "integer"
-            },
-            "rows": {
-              "items": {
-                "properties": {
-                  "disease": {
-                    "properties": {
-                      "name": {
-                        "description": "Disease name",
-                        "type": "string"
-                      }
-                    },
-                    "type": "object"
-                  },
-                  "drug": {
-                    "properties": {
-                      "maximumClinicalTrialPhase": {
-                        "description": "Max trial phase",
-                        "type": "integer"
-                      },
-                      "name": {
-                        "description": "Drug name",
-                        "type": "string"
-                      }
-                    },
-                    "type": "object"
-                  },
-                  "drugId": {
-                    "description": "Drug ID",
-                    "type": "string"
-                  },
-                  "phase": {
-                    "description": "Clinical trial phase",
-                    "type": "integer"
-                  }
-                },
-                "type": "object"
-              },
-              "type": "array"
-            }
-          },
-          "type": "object"
-        }
-      },
-      "type": "object"
-    }
-  },
-  "type": "object"
-}

addedOutput schema / properties / target

Added value: +{
+  "properties": {
+    "approvedSymbol": {
+      "type": "string"
+    },
+    "drugAndClinicalCandidates": {
+      "properties": {
+        "count": {
+          "type": "number"
+        },
+        "rows": {
+          "items": {
+            "properties": {
+              "diseases": {
+                "items": {
+                  "properties": {
+                    "disease": {
+                      "properties": {
+                        "id": {
+                          "type": "string"
+                        },
+                        "name": {
+                          "type": "string"
+                        }
+                      },
+                      "type": [
+                        "null",
+                        "object"
+                      ]
+                    },
+                    "diseaseFromSource": {
+                      "type": "string"
+                    }
+                  },
+                  "type": "object"
+                },
+                "type": "array"
+              },
+              "drug": {
+                "properties": {
+                  "drugType": {
+                    "type": "string"
+                  },
+                  "id": {
+                    "type": "string"
+                  },
+                  "name": {
+                    "type": "string"
+                  }
+                },
+                "type": "object"
+              },
+              "id": {
+                "type": "string"
+              },
+              "maxClinicalStage": {
+                "type": "string"
+              }
+            },
+            "type": "object"
+          },
+          "type": "array"
+        }
+      },
+      "type": "object"
+    },
+    "id": {
+      "type": "string"
+    }
+  },
+  "type": "object"
+}

Changed2 schema fields changedMay 22, 2026

addedInput schema / examples

Added value: +[
+  {
+    "ensembl_id": "ENSG00000141510"
+  },
+  {
+    "ensembl_id": "ENSG00000141510",
+    "size": 50
+  }
+]

changedOutput schema / (root)

Previous value: -nullNew value: +{
+  "properties": {
+    "data": {
+      "properties": {
+        "target": {
+          "properties": {
+            "approvedSymbol": {
+              "description": "Target symbol",
+              "type": "string"
+            },
+            "id": {
+              "description": "Target ID",
+              "type": "string"
+            },
+            "knownDrugs": {
+              "properties": {
+                "count": {
+                  "description": "Total known drugs",
+                  "type": "integer"
+                },
+                "rows": {
+                  "items": {
+                    "properties": {
+                      "disease": {
+                        "properties": {
+                          "name": {
+                            "description": "Disease name",
+                            "type": "string"
+                          }
+                        },
+                        "type": "object"
+                      },
+                      "drug": {
+                        "properties": {
+                          "maximumClinicalTrialPhase": {
+                            "description": "Max trial phase",
+                            "type": "integer"
+                          },
+                          "name": {
+                            "description": "Drug name",
+                            "type": "string"
+                          }
+                        },
+                        "type": "object"
+                      },
+                      "drugId": {
+                        "description": "Drug ID",
+                        "type": "string"
+                      },
+                      "phase": {
+                        "description": "Clinical trial phase",
+                        "type": "integer"
+                      }
+                    },
+                    "type": "object"
+                  },
+                  "type": "array"
+                }
+              },
+              "type": "object"
+            }
+          },
+          "type": "object"
+        }
+      },
+      "type": "object"
+    }
+  },
+  "type": "object"
+}

First observedMay 14, 2026

TDQS

Score is being calculated.

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