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Opentargets

by io.github.pipeworx-io
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Target Associations

target_associations
Read-onlyIdempotent

"What diseases is [gene] involved in" / "diseases associated with [target]" / "what does [gene] cause" — top disease associations for a drug target (Ensembl gene ID), scored by integrated Open Targets evidence (genetics, expression, animal models, drugs, literature, pathways). Use to triage what diseases a candidate target might address.

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
sizeNo1-50 (default 10)
ensembl_idYes

Output Schema

TableJSON Schema
NameRequiredDescriptionDefault
targetNo

Schema Changelog

Changes observed during successful MCP inspections.

  1. Changed2 schema fields changed
    • removedOutput schema / properties / data
      Removed value: -{
-  "properties": {
-    "target": {
-      "properties": {
-        "approvedSymbol": {
-          "description": "Target symbol",
-          "type": "string"
-        },
-        "associatedDiseases": {
-          "properties": {
-            "count": {
-              "description": "Total disease associations",
-              "type": "integer"
-            },
-            "rows": {
-              "items": {
-                "properties": {
-                  "disease": {
-                    "properties": {
-                      "id": {
-                        "description": "Disease ID",
-                        "type": "string"
-                      },
-                      "name": {
-                        "description": "Disease name",
-                        "type": "string"
-                      }
-                    },
-                    "type": "object"
-                  },
-                  "score": {
-                    "description": "Association score",
-                    "type": "number"
-                  }
-                },
-                "type": "object"
-              },
-              "type": "array"
-            }
-          },
-          "type": "object"
-        },
-        "id": {
-          "description": "Target ID",
-          "type": "string"
-        }
-      },
-      "type": "object"
-    }
-  },
-  "type": "object"
-}
    • addedOutput schema / properties / target
      Added value: +{
+  "properties": {
+    "approvedSymbol": {
+      "type": "string"
+    },
+    "associatedDiseases": {
+      "properties": {
+        "count": {
+          "type": "number"
+        },
+        "rows": {
+          "items": {
+            "properties": {
+              "disease": {
+                "properties": {
+                  "id": {
+                    "type": "string"
+                  },
+                  "name": {
+                    "type": "string"
+                  }
+                },
+                "type": "object"
+              },
+              "score": {
+                "type": "number"
+              }
+            },
+            "type": "object"
+          },
+          "type": "array"
+        }
+      },
+      "type": "object"
+    },
+    "id": {
+      "type": "string"
+    }
+  },
+  "type": "object"
+}
  2. Changed2 schema fields changed
    • addedInput schema / examples
      Added value: +[
+  {
+    "ensembl_id": "ENSG00000141510"
+  },
+  {
+    "ensembl_id": "ENSG00000141510",
+    "size": 25
+  }
+]
    • changedOutput schema / (root)
      Previous value: -nullNew value: +{
+  "properties": {
+    "data": {
+      "properties": {
+        "target": {
+          "properties": {
+            "approvedSymbol": {
+              "description": "Target symbol",
+              "type": "string"
+            },
+            "associatedDiseases": {
+              "properties": {
+                "count": {
+                  "description": "Total disease associations",
+                  "type": "integer"
+                },
+                "rows": {
+                  "items": {
+                    "properties": {
+                      "disease": {
+                        "properties": {
+                          "id": {
+                            "description": "Disease ID",
+                            "type": "string"
+                          },
+                          "name": {
+                            "description": "Disease name",
+                            "type": "string"
+                          }
+                        },
+                        "type": "object"
+                      },
+                      "score": {
+                        "description": "Association score",
+                        "type": "number"
+                      }
+                    },
+                    "type": "object"
+                  },
+                  "type": "array"
+                }
+              },
+              "type": "object"
+            },
+            "id": {
+              "description": "Target ID",
+              "type": "string"
+            }
+          },
+          "type": "object"
+        }
+      },
+      "type": "object"
+    }
+  },
+  "type": "object"
+}
  3. First observed

TDQS

Score is being calculated.

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