Opentargets

Search

search

Read-onlyIdempotent

"Find [disease / drug / gene target]" / "Open Targets lookup for [name]" / "what's the Open Targets ID for [X]" — text search across diseases, drug targets, and drugs in the Open Targets Platform (the leading drug-discovery knowledge graph). Returns ranked matches with their canonical IDs (ENSG... for targets, EFO_... for diseases, CHEMBL... for drugs). Use first to find IDs, then call target/disease/drug for details.

Input Schema

TableJSON Schema

Name	Required	Description
`size`	No	1-50 (default 10)
`query`	Yes
`entity`	No	target \| disease \| drug (omit for all)

Output Schema

TableJSON Schema

Name	Required	Description	Default
`search`	No

Schema Changelog

Changes observed during successful MCP inspections.

Changed2 schema fields changedOct 11, 2026

removedOutput schema / properties / data

Removed value: -{
-  "properties": {
-    "search": {
-      "properties": {
-        "hits": {
-          "items": {
-            "properties": {
-              "description": {
-                "description": "Entity description",
-                "type": "string"
-              },
-              "entity": {
-                "description": "Entity type (target/disease/drug)",
-                "type": "string"
-              },
-              "id": {
-                "description": "Entity ID",
-                "type": "string"
-              },
-              "name": {
-                "description": "Entity name",
-                "type": "string"
-              }
-            },
-            "type": "object"
-          },
-          "type": "array"
-        },
-        "total": {
-          "description": "Total hits",
-          "type": "integer"
-        }
-      },
-      "type": "object"
-    }
-  },
-  "type": "object"
-}

addedOutput schema / properties / search

Added value: +{
+  "properties": {
+    "hits": {
+      "items": {
+        "properties": {
+          "description": {
+            "type": "string"
+          },
+          "entity": {
+            "type": "string"
+          },
+          "id": {
+            "type": "string"
+          },
+          "name": {
+            "type": "string"
+          }
+        },
+        "type": "object"
+      },
+      "type": "array"
+    },
+    "total": {
+      "type": "number"
+    }
+  },
+  "type": "object"
+}

Changed2 schema fields changedMay 24, 2026

addedInput schema / examples

Added value: +[
+  {
+    "query": "TP53"
+  },
+  {
+    "entity": "disease",
+    "query": "cancer",
+    "size": 20
+  }
+]

changedOutput schema / (root)

Previous value: -nullNew value: +{
+  "properties": {
+    "data": {
+      "properties": {
+        "search": {
+          "properties": {
+            "hits": {
+              "items": {
+                "properties": {
+                  "description": {
+                    "description": "Entity description",
+                    "type": "string"
+                  },
+                  "entity": {
+                    "description": "Entity type (target/disease/drug)",
+                    "type": "string"
+                  },
+                  "id": {
+                    "description": "Entity ID",
+                    "type": "string"
+                  },
+                  "name": {
+                    "description": "Entity name",
+                    "type": "string"
+                  }
+                },
+                "type": "object"
+              },
+              "type": "array"
+            },
+            "total": {
+              "description": "Total hits",
+              "type": "integer"
+            }
+          },
+          "type": "object"
+        }
+      },
+      "type": "object"
+    }
+  },
+  "type": "object"
+}

First observedMay 14, 2026

TDQS

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