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Opentargets

by io.github.pipeworx-io
OverviewDiscussionsAdmin

Drug

drug
Read-onlyIdempotent

"Drug info for [ChEMBL ID]" / "look up [drug] target info" / "[CHEMBL...] mechanism" — fetch a drug profile from Open Targets by ChEMBL ID. Returns name, mechanisms of action, indications, target genes, trade names, clinical-trial phase. Use for drug research, mechanism queries.

Input Schema

NameRequiredDescriptionDefault
chembl_idYese.g. "CHEMBL1201583" (imatinib)

Output Schema

NameRequiredDescriptionDefault
drugNo

Schema Changelog

Changes observed during successful MCP inspections.

  1. Changed2 schema fields changed
    • removedOutput schema / properties / data
      Removed value: -{
-  "properties": {
-    "drug": {
-      "properties": {
-        "drugType": {
-          "description": "Drug type",
-          "type": "string"
-        },
-        "id": {
-          "description": "ChEMBL drug ID",
-          "type": "string"
-        },
-        "indications": {
-          "properties": {
-            "rows": {
-              "items": {
-                "properties": {
-                  "disease": {
-                    "properties": {
-                      "id": {
-                        "description": "Disease ID",
-                        "type": "string"
-                      },
-                      "name": {
-                        "description": "Disease name",
-                        "type": "string"
-                      }
-                    },
-                    "type": "object"
-                  },
-                  "maxPhaseForIndication": {
-                    "description": "Max phase for indication",
-                    "type": "integer"
-                  }
-                },
-                "type": "object"
-              },
-              "type": "array"
-            }
-          },
-          "type": "object"
-        },
-        "maximumClinicalTrialPhase": {
-          "description": "Max clinical trial phase",
-          "type": "integer"
-        },
-        "mechanismsOfAction": {
-          "properties": {
-            "rows": {
-              "items": {
-                "properties": {
-                  "actionType": {
-                    "description": "Mechanism action type",
-                    "type": "string"
-                  },
-                  "mechanismOfAction": {
-                    "description": "Mechanism description",
-                    "type": "string"
-                  },
-                  "targets": {
-                    "items": {
-                      "properties": {
-                        "approvedSymbol": {
-                          "description": "Target symbol",
-                          "type": "string"
-                        },
-                        "id": {
-                          "description": "Target ID",
-                          "type": "string"
-                        }
-                      },
-                      "type": "object"
-                    },
-                    "type": "array"
-                  }
-                },
-                "type": "object"
-              },
-              "type": "array"
-            }
-          },
-          "type": "object"
-        },
-        "name": {
-          "description": "Drug name",
-          "type": "string"
-        },
-        "tradeNames": {
-          "items": {
-            "description": "Trade name",
-            "type": "string"
-          },
-          "type": "array"
-        }
-      },
-      "type": "object"
-    }
-  },
-  "type": "object"
-}
    • addedOutput schema / properties / drug
      Added value: +{
+  "properties": {
+    "drugType": {
+      "type": "string"
+    },
+    "id": {
+      "type": "string"
+    },
+    "indications": {
+      "properties": {
+        "rows": {
+          "items": {
+            "properties": {
+              "disease": {
+                "properties": {
+                  "id": {
+                    "type": "string"
+                  },
+                  "name": {
+                    "type": "string"
+                  }
+                },
+                "type": "object"
+              },
+              "maxClinicalStage": {
+                "type": "string"
+              }
+            },
+            "type": "object"
+          },
+          "type": "array"
+        }
+      },
+      "type": "object"
+    },
+    "maximumClinicalStage": {
+      "type": "string"
+    },
+    "mechanismsOfAction": {
+      "properties": {
+        "rows": {
+          "items": {
+            "properties": {
+              "actionType": {
+                "type": "string"
+              },
+              "mechanismOfAction": {
+                "type": "string"
+              },
+              "targets": {
+                "items": {
+                  "properties": {
+                    "approvedSymbol": {
+                      "type": "string"
+                    },
+                    "id": {
+                      "type": "string"
+                    }
+                  },
+                  "type": "object"
+                },
+                "type": "array"
+              }
+            },
+            "type": "object"
+          },
+          "type": "array"
+        }
+      },
+      "type": "object"
+    },
+    "name": {
+      "type": "string"
+    },
+    "tradeNames": {
+      "items": {
+        "properties": {
+          "label": {
+            "type": "string"
+          },
+          "source": {
+            "type": "string"
+          }
+        },
+        "type": "object"
+      },
+      "type": "array"
+    }
+  },
+  "type": "object"
+}
  2. Changed2 schema fields changed
    • addedInput schema / examples
      Added value: +[
+  {
+    "chembl_id": "CHEMBL1201583"
+  },
+  {
+    "chembl_id": "CHEMBL25"
+  }
+]
    • changedOutput schema / (root)
      Previous value: -nullNew value: +{
+  "properties": {
+    "data": {
+      "properties": {
+        "drug": {
+          "properties": {
+            "drugType": {
+              "description": "Drug type",
+              "type": "string"
+            },
+            "id": {
+              "description": "ChEMBL drug ID",
+              "type": "string"
+            },
+            "indications": {
+              "properties": {
+                "rows": {
+                  "items": {
+                    "properties": {
+                      "disease": {
+                        "properties": {
+                          "id": {
+                            "description": "Disease ID",
+                            "type": "string"
+                          },
+                          "name": {
+                            "description": "Disease name",
+                            "type": "string"
+                          }
+                        },
+                        "type": "object"
+                      },
+                      "maxPhaseForIndication": {
+                        "description": "Max phase for indication",
+                        "type": "integer"
+                      }
+                    },
+                    "type": "object"
+                  },
+                  "type": "array"
+                }
+              },
+              "type": "object"
+            },
+            "maximumClinicalTrialPhase": {
+              "description": "Max clinical trial phase",
+              "type": "integer"
+            },
+            "mechanismsOfAction": {
+              "properties": {
+                "rows": {
+                  "items": {
+                    "properties": {
+                      "actionType": {
+                        "description": "Mechanism action type",
+                        "type": "string"
+                      },
+                      "mechanismOfAction": {
+                        "description": "Mechanism description",
+                        "type": "string"
+                      },
+                      "targets": {
+                        "items": {
+                          "properties": {
+                            "approvedSymbol": {
+                              "description": "Target symbol",
+                              "type": "string"
+                            },
+                            "id": {
+                              "description": "Target ID",
+                              "type": "string"
+                            }
+                          },
+                          "type": "object"
+                        },
+                        "type": "array"
+                      }
+                    },
+                    "type": "object"
+                  },
+                  "type": "array"
+                }
+              },
+              "type": "object"
+            },
+            "name": {
+              "description": "Drug name",
+              "type": "string"
+            },
+            "tradeNames": {
+              "items": {
+                "description": "Trade name",
+                "type": "string"
+              },
+              "type": "array"
+            }
+          },
+          "type": "object"
+        }
+      },
+      "type": "object"
+    }
+  },
+  "type": "object"
+}
  3. First observed

TDQS

B3.4/5.0
Behavior3/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

Annotations already declare readOnly, idempotent, openWorld and non-destructive, covering the safety profile. The description adds the shape of the payload (mechanisms, indications, targets, trade names, clinical-trial phase), but since an output schema exists this largely restates structured data rather than disclosing new behavioral traits like rate limits or data currency.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness3/5

Is the description appropriately sized, front-loaded, and free of redundancy?

Three quoted trigger phrases lead the description before the actual verb+resource statement, which delays the operative content. The sentence is otherwise efficient and the return-field list is compact, but the front-loading favors example queries over purpose.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness4/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

For a single-parameter, read-only lookup with an output schema and full annotations, the description supplies enough to call it correctly. The main residual gap is sibling disambiguation, which the context makes relevant but the description ignores.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters3/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

Schema coverage is 100% and the single parameter already carries an example ("CHEMBL1201583" = imatinib), so the schema fully documents the input. The description only reiterates that the key is a ChEMBL ID via its quoted trigger phrases, adding no syntax or format detail beyond the schema.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose4/5

Does the description clearly state what the tool does and how it differs from similar tools?

It names a specific verb and resource — fetch a drug profile from Open Targets by ChEMBL ID — and lists the returned fields, so the agent knows exactly what it gets back. It does not, however, distinguish itself from overlapping siblings such as target_known_drugs or target, which also surface drug/target relationships.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines3/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

'Use for drug research, mechanism queries' implies a context but gives no when-not condition and never names the alternative tools. With target_known_drugs and target_associations in the sibling list, an agent gets no explicit routing rule for choosing between them.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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