disease_associations"Best drug targets for [disease]" / "what genes are linked to [condition]" / "druggable targets in [disease]" — top drug-target candidates for a disease (EFO ID), scored by integrated evidence. Use for target discovery in a therapeutic area.
| Name | Required | Description | Default |
|---|---|---|---|
| size | No | ||
| efo_id | Yes |
| Name | Required | Description | Default |
|---|---|---|---|
| data | No |
Changes observed during successful MCP inspections.
Input schema / examplesAdded value: +[
+ {
+ "efo_id": "EFO_0000270"
+ },
+ {
+ "efo_id": "EFO_0000270",
+ "size": 15
+ }
+]Output schema / (root)Previous value: -nullNew value: +{
+ "properties": {
+ "data": {
+ "properties": {
+ "disease": {
+ "properties": {
+ "associatedTargets": {
+ "properties": {
+ "count": {
+ "description": "Total target associations",
+ "type": "integer"
+ },
+ "rows": {
+ "items": {
+ "properties": {
+ "score": {
+ "description": "Association score",
+ "type": "number"
+ },
+ "target": {
+ "properties": {
+ "approvedName": {
+ "description": "Target name",
+ "type": "string"
+ },
+ "approvedSymbol": {
+ "description": "Target symbol",
+ "type": "string"
+ },
+ "id": {
+ "description": "Target ID",
+ "type": "string"
+ }
+ },
+ "type": "object"
+ }
+ },
+ "type": "object"
+ },
+ "type": "array"
+ }
+ },
+ "type": "object"
+ },
+ "id": {
+ "description": "Disease ID",
+ "type": "string"
+ },
+ "name": {
+ "description": "Disease name",
+ "type": "string"
+ }
+ },
+ "type": "object"
+ }
+ },
+ "type": "object"
+ }
+ },
+ "type": "object"
+}Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?
Annotations already indicate read-only, idempotent, and non-destructive behavior. The description adds context about the tool's ranking/scoring mechanism ('scored by integrated evidence') and that it returns 'top' candidates, which goes beyond the annotations. No contradictions found.
Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.
Is the description appropriately sized, front-loaded, and free of redundancy?
The description is concise and well-structured, starting with example queries, followed by a clear definition and usage guidance. Every sentence contributes to understanding, with no filler or redundancy.
Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.
Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?
With an output schema present and good annotations, the description does not need to explain return values. It gives sufficient context for target discovery, but it does not mention pagination, result limits, or any constraints on the size parameter, which is a minor gap.
Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.
Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?
Schema description coverage is 0%, so the description must compensate. It explains efo_id as a disease identifier, but does not explain the optional 'size' parameter. Since efo_id is the required parameter and size is likely straightforward (number of results), partial compensation warrants a mid-range score.
Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.
Does the description clearly state what the tool does and how it differs from similar tools?
The description clearly specifies that the tool returns top drug-target candidates for a disease, using an EFO ID as input. It includes example queries that illustrate the use case, and the focus on disease distinguishes it from sibling tools like target_associations or target_known_drugs.
Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.
Does the description explain when to use this tool, when not to, or what alternatives exist?
The description provides clear usage context: 'Use for target discovery in a therapeutic area' and gives example natural-language queries. However, it does not explicitly mention alternatives or when not to use this tool, so it stops short of full exclusion guidance.
Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.
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