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20 Best Email MCP Servers: compared and ranked, November 2026Ranked from 3,360 matching servers on stars, growth, downloads and maintenance. Updated .

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GET /v1/servers – MCP directory API reference
  • A
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    Enables AI agents to resolve and cross-reference biological entities such as genes, proteins, and aliases across authoritative databases like HGNC, NCBI Entrez, and UniProt, with confidence scores and source citations.
    16
    2
    Apache 2.0
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    license
    Not graded
    quality
    B
    maintenance
    Enables AI agents to search EBI BioSamples metadata for biological samples such as cell lines, tissues, and organisms by free-text keyword, and to fetch individual records by accession to retrieve taxId, organism, and characteristics like tissue, sex, and cell type. It can run as a hosted gateway endpoint or locally over stdio via npx.
    412 npm
    MIT
  • A
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    quality
    C
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    Provides a natural language interface for scRNA-Seq analysis using the Scanpy library, supporting operations such as data preprocessing, clustering, and visualization. It enables AI agents and clients to perform complex single-cell transcriptomics workflows through the Model Context Protocol.
    26 PyPI
    2
    BSD 3-Clause
  • A
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    B
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    Enables AI agents to resolve marine species names to OBIS taxon records, retrieve georeferenced ocean occurrence records with optional date filtering, and pull aggregate statistics such as record counts, contributing datasets, and observed year ranges. Queries the Ocean Biodiversity Information System keylessly over the Pipeworx gateway or as a local stdio server.
    339 npm
    MIT
  • A
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    quality
    C
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    Enables looking up drug and molecule data — identifiers such as InChIKey, SMILES, CAS, and ChEMBL IDs, plus measured and computed properties and drug information — across PubChem, ChEMBL, and Wikidata. Every returned value carries its cited source, and it covers small molecules, peptides (including modified and cyclic forms), and conjugates such as antibody–drug conjugates.
    Apache 2.0
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    B
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    Enables users to search and retrieve 3D cryo-EM and electron-tomography density maps by keyword or entry ID, returning details such as resolution, structure-determination method, sample, and release date.
    449 npm
    1
    MIT
  • A
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    B
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    Enables searching EBI BioStudies, a keyless database of biological study descriptions, by keyword and retrieving full metadata for a single study by accession, including title, abstract, release date, and link counts. Results tie studies across EBI archives such as ArrayExpress and PRIDE, so agents can locate and inspect study records without authentication.
    394 npm
    MIT
  • A
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    A
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    Enables language models to search biomedical literature, fetch sequences, and follow links across Entrez databases through eleven read-only tools wrapping the nine NCBI Entrez E-utilities. It handles URL building, pacing, redirects, response caps, and API-key redaction so queries can be answered without a browser or scraping.
    11
    MIT
  • A
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    quality
    B
    maintenance
    Enables MCP clients to annotate and classify single human genetic variants in any notation, returning an auditable points-based ACMG verdict with its criteria, gnomAD frequencies, in-silico predictors, ClinVar data, and per-transcript consequences. It is read-only, requires no account or API key, and keeps answers compact while linking back to the source.
    6
    MIT
  • A
    license
    A
    quality
    D
    maintenance
    Enables AI assistants to rapidly gather and synthesize structural, chemical, conservation, and literature data about protein binding pockets for drug-target triage. Useful as a reconnaissance step before computational binder design.
    8
    1
    MIT
  • A
    license
    A
    quality
    A
    maintenance
    A bridge connecting AI agents to NCBI's PubMed database through the Model Context Protocol, enabling seamless searching, retrieval, and analysis of biomedical literature and data.
    12
    3,435 npm
    166
    Apache 2.0
  • A
    license
    A
    quality
    C
    maintenance
    Enables LLM agents to search EMDB cryo-EM maps, look up UniProt proteins, compute ESM-2 sequence embeddings, retrieve cryo-EM maps from a protein sequence via a two-tower model, and search GEO DNA-methylation arrays, all through typed tools with structured output. Ships with a 40-question evaluation harness that runs Claude as the MCP client.
    3
    MIT
  • A
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    A
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    An MCP server that gives AI assistants access to biological and biomedical RDF databases via SPARQL at the RDF Portal, as well as selected REST APIs (NCBI E-utilities, UniProt, ChEMBL, PDB, Reactome, Rhea, MeSH, and more).
    2
    29
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    MIT
  • A
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    Enables AI assistants to query the eggNOG 7 database in natural language for protein lookups, orthologous groups, pairwise orthologs, protein families, taxonomy, and database statistics. Also delivers structured functional annotations such as KEGG KO and GO terms with confidence scores, plus an index of bulk-downloadable data files.
    10
    1
    MIT
  • A
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    A
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    C
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    Enables LLM-powered applications to look up bacterial and archaeal taxonomy, search genomes, browse and navigate the taxonomic tree, and compare genomes or find phylogenetic paths between taxa. It works out of the box with a built-in reference dataset covering major phyla and can be pointed at full Genome Taxonomy Database TSV files for comprehensive queries.
    12
    1
    MIT
  • A
    license
    A
    quality
    C
    maintenance
    Enables AI assistants to submit genomic sequences or NCBI accessions to antiSMASH for secondary metabolite biosynthetic gene cluster analysis, check job status, retrieve and download results, and query server status across bacteria, fungi, and plant servers.
    10
    1
    MIT
  • A
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    A
    quality
    C
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    Enables users to search rRNA sequences by organism, accession, or taxonomy, retrieve detailed sequence metadata, evaluate probes and primer pairs, and list available databases and taxonomies through MCP tools.
    6
    1
    MIT
  • A
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    A
    quality
    A
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    Reads raw lab-instrument files (microscopy, mass spectrometry, chromatography, flow cytometry, NMR, electrophysiology, spectroscopy, plate readers, qPCR) without vendor software, returning metadata, images, spectra and traces as JSON. It also checks files for damage, runs common analyses, and exports to open formats such as OME-TIFF, OME-Zarr, mzML, Parquet and NWB.
    28
    284 PyPI
    10
    Apache 2.0
  • A
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    Enables AI-powered genomic variant analysis including variant impact prediction, regulatory element discovery, and batch variant scoring. Currently operates in mock mode as a proof-of-concept awaiting the public release of Google DeepMind's AlphaGenome API.
    24
    27 npm
    2
    MIT
  • A
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    B
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    Exposes phylogenetic tree validation, analysis, styling, export, and Java-based rendering as 21 MCP tools, 3 resources, and 2 prompts for AI assistants. Delegates parsing and rendering to the FigTreeKit kernel, returning reproducible CLI commands and structured artifacts.
    21
    1
    GPL 2.0
  • F
    license
    B
    quality
    D
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    Enables users to generate volcano plots by submitting jobs with input files and parameters, supporting local or Docker execution.
    8
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  • F
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    B
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    Exposes the NGS360 bioinformatics platform REST API as MCP tools, enabling AI assistants to manage sequencing runs, projects, workflows, and more through natural language.
    82
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  • A
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    B
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    Enables searching ENA's public sequencing data by organism, study, platform, country or date, retrieving FASTQ/BAM download URLs and checksums, and discovering available result types and fields.
    454 npm
    MIT
  • A
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    B
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    Enables AI agents to search public cancer genomics studies (TCGA, CPTAC, MSK, and more), fetch full details for individual studies, resolve gene symbols to Entrez ids, and list cancer types. Works keylessly against open cBioPortal data over a hosted MCP endpoint, a local stdio server, or plain HTTP.
    414 npm
    MIT