PROSPERO MCP Server

MCP server for the PROSPERO international prospective register of systematic reviews.

Enables AI assistants to search registered systematic review protocols, look up individual CRD records, explore the MeSH vocabulary, check for possibly duplicate/overlapping reviews, and export results in RIS format.

Tools

• search_prospero - search the register (15 fields: ALL/TI/CS/IV/OP/OS/CM/PA/RQ/KW/CO/AN/NC/OA/FU)

• get_prospero_record - look up a record by registration number (e.g. CRD42023407478)

• search_mesh - search the MeSH vocabulary

• check_duplicate_review - find possibly already-registered reviews (manual review required)

• export_search_ris - export results as RIS for Zotero/EndNote/RevMan

• search_prospero_advanced - Boolean search: "(diabetes):TI AND (metformin):ALL"

• search_prospero_stats - total hit counts and aggregations for a query

Run locally

pip install -r requirements.txt
python prospero_server.py

MCP endpoint: http://localhost:8000/mcp (Streamable HTTP)

Deploy

The included Dockerfile runs the server bound to $PORT (default 8000) on 0.0.0.0, suitable for Railway, Render, Fly.io, etc.