GxP MDM MCP Server

Claude / ChatGPT / Cursor
        |
        | MCP (stdio)
        v
  mcp_server.py (14 tools)
        |
        | Cypher queries
        v
  Neo4j (or MOCK mode: NetworkX + JSON) <- your MDM golden record

cd gxp_mdm_mcp_server
pip install -r requirements.txt

# Mock mode: uses JSON + NetworkX, no Neo4j required
python scripts/test_tools.py

# Should show:
# - List 4 systems
# - Veeva QMS details with downstream SAP
# - Blast radius: Veeva -> SAP
# - REJECT for audit trail purge
# - Minor for version upgrade

# .env - set Neo4j creds
cp .env.example .env
# Edit .env with your Neo4j URI

# Start Neo4j
docker-compose up -d neo4j

# Load sample data + schema
python scripts/load_sample_data.py

# Test with Neo4j
python scripts/test_tools.py

# Start API harness (optional)
uvicorn src.api_server:app --reload --port 8000
# http://localhost:8000/cypher/list_all_systems
# http://localhost:8000/cypher/blast_radius?system_id=SYS-VEEVA-QMS-001

{
  "mcpServers": {
    "gxp-mdm-cypher": {
      "command": "python",
      "args": ["/absolute/path/to/gxp_mdm_mcp_server/src/mcp_server.py"],
      "env": {
        "NEO4J_URI": "",
        "NEO4J_USERNAME": "neo4j",
        "NEO4J_PASSWORD": "password"
      }
    }
  }
}

List all GxP Direct systems in my inventory
> calls list_all_systems(gxp_impact="Direct")

What happens if I change Veeva QMS? Show blast radius
> calls get_blast_radius(system_id="SYS-VEEVA-QMS-001")

Assess this change: Enable audit trail purge after 7 years for Veeva QMS
> calls assess_change_impact -> should REJECT per 21CFR11.10(e)

Assess Veeva upgrade from 24R1 to 24R2 with no e-sig change
> calls assess_change_impact -> should be Minor per CSA low risk

MATCH (start:ComputerizedSystem {system_id: $system_id})
MATCH path = (start)-[:SENDS_VIA*1..$depth]->(downstream:ComputerizedSystem)
WHERE downstream.gxp_impact IN ['Direct', 'GxP Relevant']
RETURN downstream.system_id, length(path) as distance

MATCH (s:ComputerizedSystem {system_id: $system_id})
OPTIONAL MATCH (s)-[:HAS_FUNCTION]->(f)-[:REGULATED_BY]->(reg)
RETURN collect(DISTINCT reg) as regulations

You: Change Veeva QMS status to Validated - Change Implemented, reason: IQ/OQ passed for 24R2 upgrade, requested by qa.john

Claude calls:
request_validation_status_change_tool(system_id="SYS-VEEVA-QMS-001", new_status="Validated - Change Implemented", reason="IQ/OQ passed for 24R2 upgrade, evidence in Veeva Vault VP-2024-089", requested_by="qa.john@company.com")

-> Returns request_id CHG-VAL-A1B2C3, status Pending Approval

You: Approve CHG-VAL-A1B2C3 by qa.sarah, comment: Reviewed IQ/OQ, approved

Claude calls:
approve_validation_status_change_tool(request_id="CHG-VAL-A1B2C3", approver="qa.sarah@company.com", approval_comment="Reviewed IQ/OQ")

-> Applies change, updates sample_systems.json, creates audit trail with e-signature

You: Show audit trail for Veeva QMS

Claude calls:
get_audit_trail_tool(system_id="SYS-VEEVA-QMS-001")
-> Returns who, when, old/new, reason, electronic signature manifestation

curl -X POST http://localhost:8000/request-status-change -H "Content-Type: application/json" -d '{"system_id":"SYS-VEEVA-QMS-001","new_status":"Validated - Change Implemented","reason":"IQ/OQ passed for 24R2 upgrade","requested_by":"qa.john@company.com"}'

curl -X POST http://localhost:8000/approve-status-change -d '{"request_id":"CHG-VAL-A1B2C3","approver":"qa.sarah@company.com","approval_comment":"Reviewed"}'

curl http://localhost:8000/audit-trail?system_id=SYS-VEEVA-QMS-001

# Run once manually
python -c "from src.periodic_review_agent.agent import agent; print(agent.scan_overdue())"

# Generate drafts
python -c "from src.periodic_review_agent.agent import agent; print(agent.generate_drafts_for_overdue())"

# Run as daemon (daily 8am + every 6h demo)
python src/periodic_review_agent/scheduler.py

You: Run periodic review scan

Claude calls run_periodic_review_scan() -> finds 2 overdue systems

You: Generate drafts for overdue

Claude calls generate_periodic_review_drafts() -> creates PR-SYS-VEEVA-QMS-001-2025-XXXX reports

You: Show me draft for Veeva QMS
> Returns full 10-section report