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Renal Transtubular Potassium Gradient (TTKG) Skill

Renal Transtubular Potassium Gradient (TTKG) Skill

Renal Transtubular Potassium Gradient (TTKG) Skill

License Python OpenClaw GenPark MCP

Renal Transtubular Potassium Gradient (TTKG) and Distal Tubular Secretion Evaluator based on nephrological electrolyte physiology.

flowchart TD
    A[Urine & Plasma Potassium + Osmolality] --> B[Check Validity: U_osm >= P_osm]
    B --> C[Compute TTKG = U_K * P_osm / P_K * U_osm]
    C --> D{Serum Potassium Level}
    D -- Hyperkalemia > 5.0 --> E{TTKG > 7.0?}
    E -- Yes --> F[Appropriate Aldosterone Secretion]
    E -- No --> G[Hypoaldosteronism / Type IV RTA]
    D -- Hypokalemia < 3.5 --> H{TTKG < 3.0?}
    H -- Yes --> I[Appropriate Extra-Renal K Loss]
    H -- No --> J[Inappropriate Renal K Wasting]

Features

  • Zero PIP Dependencies: Implemented strictly with Python Standard Library (math, json, sys, typing).

  • Physiological Verification: Automatically validates urine-to-plasma osmolality ratio and distal sodium delivery conditions.

  • Electrolyte Precision: Rigorous algorithmic discrimination between mineralocorticoid deficiency, excess, and extra-renal losses.

  • Dual Architecture: Native Python import and Model Context Protocol (MCP) JSON-RPC 2.0 stdio server.

Related MCP server: Personal Agent Hydration Osmolality Electrolyte MCP Server

Quickstart

python example_usage.py

License

Apache-2.0

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