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���}�(�data�}��articles�]�(}�(�pmid��35100407��title��.Linkage disequilibrium between rare mutations.��authors�]��Benjamin H Good�a�journal��Genetics��publication_date��2022-Apr��abstract�XuThe statistical associations between mutations, collectively known as linkage disequilibrium, encode important information about the evolutionary forces acting within a population. Yet in contrast to single-site analogues like the site frequency spectrum, our theoretical understanding of linkage disequilibrium remains limited. In particular, little is currently known about how mutations with different ages and fitness costs contribute to expected patterns of linkage disequilibrium, even in simple settings where recombination and genetic drift are the major evolutionary forces. Here, I introduce a forward-time framework for predicting linkage disequilibrium between pairs of neutral and deleterious mutations as a function of their present-day frequencies. I show that the dynamics of linkage disequilibrium become much simpler in the limit that mutations are rare, where they admit a simple heuristic picture based on the trajectories of the underlying lineages. I use this approach to derive analytical expressions for a family of frequency-weighted linkage disequilibrium statistics as a function of the recombination rate, the frequency scale, and the additive and epistatic fitness costs of the mutations. I find that the frequency scale can have a dramatic impact on the shapes of the resulting linkage disequilibrium curves, reflecting the broad range of time scales over which these correlations arise. I also show that the differences between neutral and deleterious linkage disequilibrium are not purely driven by differences in their mutation frequencies and can instead display qualitative features that are reminiscent of epistasis. I conclude by discussing the implications of these results for recent linkage disequilibrium measurements in bacteria. This forward-time approach may provide a useful framework for predicting linkage disequilibrium across a range of evolutionary scenarios.��doi��10.1093/genetics/iyac004��
mesh_terms�]�(�Biological Evolution��
Genetic Drift��Linkage Disequilibrium��Models, Genetic��Mutation��
Mutation Rate��Selection, Genetic�eu}�(h�27294413�h�IHuman genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016.�h
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L. Pollard��T. Wood��F. Luo��R. Stevenson��R. Polimanti��J. Gelernter��X. Lin��	I. Y. Lim��Y. Wu��	A. L. Teh��L. Chen��
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M. T. Tint��J. L. MacIsaac��F. Yap��K. Kwek��	S. M. Saw��M. S. Kobor��M. J. Meaney��
K. M. Godfrey��Y. S. Chong��J. D. Holbrook��	Y. S. Lee��P. D. Gluckman��
N. Karnani��	A. Kapoor��D. Lee��A. Chakravarti��C. Maercker��F. Graf��
M. Boutros��G. Stamoulis��
F. Santoni��P. Makrythanasis��
A. Letourneau��M. Guipponi��N. Panousis��
M. Garieri��	P. Ribaux��E. Falconnet��C. Borel��S. E. Antonarakis��S. Kumar��	J. Curran��J. Blangero��
S. Chatterjee��	A. Kapoor��
J. Akiyama��D. Auer��
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L. Pennacchio��A. Chakravarti��T. R. Donti��G. Cappuccio��	M. Miller��P. Atwal��
A. Kennedy��	A. Cardon��	C. Bacino��	L. Emrick��J. Hertecant��	F. Baumer��	B. Porter��
M. Bainbridge��	P. Bonnen��	B. Graham��	R. Sutton��Q. Sun��S. Elsea��Z. Hu��P. Wang��Y. Zhu��J. Zhao��M. Xiong��David A. Bennett��A. Hidalgo-Miranda��S. Romero-Cordoba��S. Rodriguez-Cuevas��R. Rebollar-Vega��E. Tagliabue��M. Iorio��E. D’Ippolito��	S. Baroni��
B. Kaczkowski��	Y. Tanaka��	H. Kawaji��A. Sandelin��R. Andersson��M. Itoh��T. Lassmann��Y. Hayashizaki��P. Carninci��A. R. R. Forrest��C. A. Semple��E. A. Rosenthal��	B. Shirts��L. Amendola��
C. Gallego��M. Horike-Pyne��A. Burt��P. Robertson��	P. Beyers��C. Nefcy��D. Veenstra��	F. Hisama��
R. Bennett��M. Dorschner��D. Nickerson��J. Smith��K. Patterson��D. Crosslin��	R. Nassir��	N. Zubair��T. Harrison��	U. Peters��	G. Jarvik��	F. Menghi��K. Inaki��X. Woo��P. Kumar��	K. Grzeda��A. Malhotra��H. Kim��D. Ucar��P. Shreckengast��K. Karuturi��J. Keck��	J. Chuang��	E. T. Liu��B. Ji��A. Tyler��	G. Ananda��	G. Carter��H. Nikbakht��M. Montagne��
M. Zeinieh��A. Harutyunyan��M. Mcconechy��	N. Jabado��
P. Lavigne��J. Majewski��J. B. Goldstein��
M. Overman��G. Varadhachary��	R. Shroff��R. Wolff��M. Javle��
A. Futreal��D. Fogelman��L. Bravo��
W. Fajardo��H. Gomez��C. Castaneda��C. Rolfo��J. A. Pinto��
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A. Futreal��S. Patterson��C. Statz��	S. Mockus��S. N. Nikolaev��
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L. Parmentier��B. King��F. Bezrukov��G. Kaya��V. Zoete��V. Seplyarskiy��	H. Sharpe��T. McKee��
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M. Garieri��	C. Verdan��K. Grosdemange��	O. Sumara��	M. Eilers��I. Aifantis��O. Michielin��
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S. Lincoln��	A. Kurian��
A. Desmond��S. Yang��Y. Kobayashi��J. Ford��
L. Ellisen��T. L. Peters��
K. R. Alvarez��E. F. Hollingsworth��D. H. Lopez-Terrada��	A. Hastie��
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A. W. Pang��	E. T. Lam��T. Anantharaman��M. Saghbini��H. Cao��C. Gonzaga-Jauregui��L. Ma��A. King��E. Berman Rosenzweig��U. Krishnan��
J. G. Reid��
J. D. Overton��F. Dewey��W. K. Chung��K. Small��	A. DeLuca��
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�Human genomics�h�2016-May�hXE3O1 The metabolomics approach to autism: identification of biomarkers for early detection of autism spectrum disorder A. K. Srivastava, Y. Wang, R. Huang, C. Skinner, T. Thompson, L. Pollard, T. Wood, F. Luo, R. Stevenson O2 Phenome-wide association study for smoking- and drinking-associated genes in 26,394 American women with African, Asian, European, and Hispanic descents R. Polimanti, J. Gelernter O3 Effects of prenatal environment, genotype and DNA methylation on birth weight and subsequent postnatal outcomes: findings from GUSTO, an Asian birth cohort X. Lin, I. Y. Lim, Y. Wu, A. L. Teh, L. Chen, I. M. Aris, S. E. Soh, M. T. Tint, J. L. MacIsaac, F. Yap, K. Kwek, S. M. Saw, M. S. Kobor, M. J. Meaney, K. M. Godfrey, Y. S. Chong, J. D. Holbrook, Y. S. Lee, P. D. Gluckman, N. Karnani, GUSTO study group O4 High-throughput identification of specific qt interval modulating enhancers at the SCN5A locus A. Kapoor, D. Lee, A. Chakravarti O5 Identification of extracellular matrix components inducing cancer cell migration in the supernatant of cultivated mesenchymal stem cells C. Maercker, F. Graf, M. Boutros O6 Single cell allele specific expression (ASE) IN T21 and common trisomies: a novel approach to understand DOWN syndrome and other aneuploidies G. Stamoulis, F. Santoni, P. Makrythanasis, A. Letourneau, M. Guipponi, N. Panousis, M. Garieri, P. Ribaux, E. Falconnet, C. Borel, S. E. Antonarakis O7 Role of microRNA in LCL to IPSC reprogramming S. Kumar, J. Curran, J. Blangero O8 Multiple enhancer variants disrupt gene regulatory network in Hirschsprung disease S. Chatterjee, A. Kapoor, J. Akiyama, D. Auer, C. Berrios, L. Pennacchio, A. Chakravarti O9 Metabolomic profiling for the diagnosis of neurometabolic disorders T. R. Donti, G. Cappuccio, M. Miller, P. Atwal, A. Kennedy, A. Cardon, C. Bacino, L. Emrick, J. Hertecant, F. Baumer, B. Porter, M. Bainbridge, P. Bonnen, B. Graham, R. Sutton, Q. Sun, S. 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Fogelman O19 DDIT4 gene expression as a prognostic marker in several malignant tumors L. Bravo, W. Fajardo, H. Gomez, C. Castaneda, C. Rolfo, J. A. Pinto O20 Spatial organization of the genome and genomic alterations in human cancers K. C. Akdemir, L. Chin, A. Futreal, ICGC PCAWG Structural Alterations Group O21 Landscape of targeted therapies in solid tumors S. Patterson, C. Statz, S. Mockus O22 Genomic analysis reveals novel drivers and progression pathways in skin basal cell carcinoma S. N. Nikolaev, X. I. Bonilla, L. Parmentier, B. King, F. Bezrukov, G. Kaya, V. Zoete, V. Seplyarskiy, H. Sharpe, T. McKee, A. Letourneau, P. Ribaux, K. Popadin, N. Basset-Seguin, R. Ben Chaabene, F. Santoni, M. Andrianova, M. Guipponi, M. Garieri, C. Verdan, K. Grosdemange, O. Sumara, M. Eilers, I. Aifantis, O. Michielin, F. de Sauvage, S. Antonarakis O23 Identification of differential biomarkers of hepatocellular carcinoma and cholangiocarcinoma via transcriptome microarray meta-analysis S. Likhitrattanapisal O24 Clinical validity and actionability of multigene tests for hereditary cancers in a large multi-center study S. Lincoln, A. Kurian, A. Desmond, S. Yang, Y. Kobayashi, J. Ford, L. Ellisen O25 Correlation with tumor ploidy status is essential for correct determination of genome-wide copy number changes by SNP array T. L. Peters, K. R. Alvarez, E. F. Hollingsworth, D. H. Lopez-Terrada O26 Nanochannel based next-generation mapping for interrogation of clinically relevant structural variation A. Hastie, Z. Dzakula, A. W. Pang, E. T. Lam, T. Anantharaman, M. Saghbini, H. Cao, BioNano Genomics O27 Mutation spectrum in a pulmonary arterial hypertension (PAH) cohort and identification of associated truncating mutations in TBX4 C. Gonzaga-Jauregui, L. Ma, A. King, E. Berman Rosenzweig, U. Krishnan, J. G. Reid, J. D. Overton, F. Dewey, W. K. Chung O28 NORTH CAROLINA macular dystrophy (MCDR1): mutations found affecting PRDM13 K. Small, A. DeLuca, F. Cremers, R. A. Lewis, V. Puech, B. Bakall, R. Silva-Garcia, K. Rohrschneider, M. Leys, F. S. Shaya, E. Stone O29 PhenoDB and genematcher, solving unsolved whole exome sequencing data N. L. Sobreira, F. Schiettecatte, H. Ling, E. Pugh, D. Witmer, K. Hetrick, P. Zhang, K. Doheny, D. Valle, A. Hamosh O30 Baylor-Johns Hopkins Center for Mendelian genomics: a four year review S. N. Jhangiani, Z. Coban Akdemir, M. N. Bainbridge, W. Charng, W. Wiszniewski, T. Gambin, E. Karaca, Y. Bayram, M. K. Eldomery, J. Posey, H. Doddapaneni, J. Hu, V. R. Sutton, D. M. Muzny, E. A. Boerwinkle, D. Valle, J. R. Lupski, R. A. Gibbs O31 Using read overlap assembly to accurately identify structural genetic differences in an ashkenazi jewish trio S. Shekar, W. Salerno, A. English, A. Mangubat, J. Bruestle O32 Legal interoperability: a sine qua non for international data sharing A. Thorogood, B. M. Knoppers, Global Alliance for Genomics and Health - Regulatory and Ethics Working Group O33 High throughput screening platform of competent sineups: that can enhance translation activities of therapeutic target H. Takahashi, K. R. Nitta, A. Kozhuharova, A. M. Suzuki, H. Sharma, D. Cotella, C. Santoro, S. Zucchelli, S. Gustincich, P. Carninci O34 The undiagnosed diseases network international (UDNI): clinical and laboratory research to meet patient needs J. J. Mulvihill, G. Baynam, W. Gahl, S. C. Groft, K. Kosaki, P. Lasko, B. Melegh, D. Taruscio O36 Performance of computational algorithms in pathogenicity predictions for activating variants in oncogenes versus loss of function mutations in tumor suppressor genes R. Ghosh, S. Plon O37 Identification and electronic health record incorporation of clinically actionable pharmacogenomic variants using prospective targeted sequencing S. Scherer, X. Qin, R. Sanghvi, K. Walker, T. Chiang, D. Muzny, L. Wang, J. Black, E. Boerwinkle, R. Weinshilboum, R. Gibbs O38 Melanoma reprogramming state correlates with response to CTLA-4 blockade in metastatic melanoma T. Karpinets, T. Calderone, K. Wani, X. Yu, C. Creasy, C. Haymaker, M. Forget, V. Nanda, J. Roszik, J. Wargo, L. Haydu, X. Song, A. Lazar, J. Gershenwald, M. Davies, C. Bernatchez, J. Zhang, A. Futreal, S. Woodman O39 Data-driven refinement of complex disease classification from integration of heterogeneous functional genomics data in GeneWeaver E. J. Chesler, T. Reynolds, J. A. Bubier, C. Phillips, M. A. Langston, E. J. Baker O40 A general statistic framework for genome-based disease risk prediction M. Xiong, L. Ma, N. Lin, C. Amos O41 Integrative large-scale causal network analysis of imaging and genomic data and its application in schizophrenia studies N. Lin, P. Wang, Y. Zhu, J. Zhao, V. Calhoun, M. Xiong O42 Big data and NGS data analysis: the cloud to the rescue O. Dobretsberger, M. Egger, F. Leimgruber O43 Cpipe: a convergent clinical exome pipeline specialised for targeted sequencing S. Sadedin, A. Oshlack, Melbourne Genomics Health Alliance O44 A Bayesian classification of biomedical images using feature extraction from deep neural networks implemented on lung cancer data V. A. A. Antonio, N. Ono, Clark Kendrick C. Go O45 MAV-SEQ: an interactive platform for the Management, Analysis, and Visualization of sequence data Z. Ahmed, M. Bolisetty, S. Zeeshan, E. Anguiano, D. Ucar O47 Allele specific enhancer in EPAS1 intronic regions may contribute to high altitude adaptation of Tibetans C. Zeng, J. Shao O48 Nanochannel based next-generation mapping for structural variation detection and comparison in trios and populations H. Cao, A. Hastie, A. W. Pang, E. T. Lam, T. Liang, K. Pham, M. Saghbini, Z. Dzakula O49 Archaic introgression in indigenous populations of Malaysia revealed by whole genome sequencing Y. Chee-Wei, L. Dongsheng, W. Lai-Ping, D. Lian, R. O. Twee Hee, Y. Yunus, F. Aghakhanian, S. S. Mokhtar, C. V. Lok-Yung, J. Bhak, M. Phipps, X. Shuhua, T. Yik-Ying, V. Kumar, H. Boon-Peng O50 Breast and ovarian cancer prevention: is it time for population-based mutation screening of high risk genes? I. Campbell, M.-A. Young, P. James, Lifepool O53 Comprehensive coverage from low DNA input using novel NGS library preparation methods for WGS and WGBS C. Schumacher, S. Sandhu, T. Harkins, V. Makarov O54 Methods for large scale construction of robust PCR-free libraries for sequencing on Illumina HiSeqX platform H. DoddapaneniR. Glenn, Z. Momin, B. Dilrukshi, H. Chao, Q. Meng, B. Gudenkauf, R. Kshitij, J. Jayaseelan, C. Nessner, S. Lee, K. Blankenberg, L. Lewis, J. Hu, Y. Han, H. Dinh, S. Jireh, K. Walker, E. Boerwinkle, D. Muzny, R. Gibbs O55 Rapid capture methods for clinical sequencing J. Hu, K. Walker, C. Buhay, X. Liu, Q. Wang, R. Sanghvi, H. Doddapaneni, Y. Ding, N. Veeraraghavan, Y. Yang, E. Boerwinkle, A. L. Beaudet, C. M. Eng, D. M. Muzny, R. A. Gibbs O56 A diploid personal human genome model for better genomes from diverse sequence data K. C. C. Worley, Y. Liu, D. S. T. Hughes, S. C. Murali, R. A. Harris, A. C. English, X. Qin, O. A. Hampton, P. Larsen, C. Beck, Y. Han, M. Wang, H. Doddapaneni, C. L. Kovar, W. J. Salerno, A. Yoder, S. Richards, J. Rogers, J. R. Lupski, D. M. Muzny, R. A. Gibbs O57 Development of PacBio long range capture for detection of pathogenic structural variants Q. Meng, M. Bainbridge, M. Wang, H. Doddapaneni, Y. Han, D. Muzny, R. Gibbs O58 Rhesus macaques exhibit more non-synonymous variation but greater impact of purifying selection than humans R. A. Harris, M. Raveenedran, C. Xue, M. Dahdouli, L. Cox, G. Fan, B. Ferguson, J. Hovarth, Z. Johnson, S. Kanthaswamy, M. Kubisch, M. Platt, D. Smith, E. Vallender, R. Wiseman, X. Liu, J. Below, D. Muzny, R. Gibbs, F. Yu, J. Rogers O59 Assessing RNA structure disruption induced by single-nucleotide variation J. Lin, Y. Zhang, Z. Ouyang P1 A meta-analysis of genome-wide association studies of mitochondrial dna copy number A. Moore, Z. Wang, J. Hofmann, M. Purdue, R. Stolzenberg-Solomon, S. Weinstein, D. Albanes, C.-S. Liu, W.-L. Cheng, T.-T. Lin, Q. Lan, N. Rothman, S. Berndt P2 Missense polymorphic genetic combinations underlying down syndrome susceptibility E. S. Chen P4 The evaluation of alteration of ELAM-1 expression in the endometriosis patients H. Bahrami, A. Khoshzaban, S. Heidari Keshal P5 Obesity and the incidence of apolipoprotein E polymorphisms in an assorted population from Saudi Arabia population K. K. R. Alharbi P6 Genome-associated personalized antithrombotical therapy for patients with high risk of thrombosis and bleeding M. Zhalbinova, A. Akilzhanova, S. Rakhimova, M. Bekbosynova, S. Myrzakhmetova P7 Frequency of Xmn1 polymorphism among sickle cell carrier cases in UAE population M. Matar P8 Differentiating inflammatory bowel diseases by using genomic data: dimension of the problem and network organization N. Mili, R. Molinari, Y. Ma, S. Guerrier P9 Vulnerability of genetic variants to the risk of autism among Saudi children N. Elhawary, M. Tayeb, N. Bogari, N. Qotb P10 Chromatin profiles from ex vivo purified dopaminergic neurons establish a promising model to support studies of neurological function and dysfunction S. A. McClymont, P. W. Hook, L. A. Goff, A. McCallion P11 Utilization of a sensitized chemical mutagenesis screen to identify genetic modifiers of retinal dysplasia in homozygous Nr2e3�h�10.1186/s40246-016-0063-5�h]�u}�(h�27534393�h�925th Annual Computational Neuroscience Meeting: CNS-2016.�h
]�(�Tatyana O. Sharpee��Alain Destexhe��
Mitsuo Kawato��Vladislav Sekulić��Frances K. Skinner��Daniel K. Wójcik��Chaitanya Chintaluri��Dorottya Cserpán��Zoltán Somogyvári��Jae Kyoung Kim��Zachary P. Kilpatrick��Matthew R. Bennett��Kresimir Josić��Irene Elices��David Arroyo��Rafael Levi��Francisco B. Rodriguez��Pablo Varona��Eunjin Hwang��	Bowon Kim��Hio-Been Han��Tae Kim��James T. McKenna��Ritchie E. Brown��Robert W. McCarley��
Jee Hyun Choi��James Rankin��Pamela Osborn Popp��John Rinzel��Alejandro Tabas��André Rupp��Emili Balaguer-Ballester��Matias I. Maturana��David B. Grayden��Shaun L. Cloherty��Tatiana Kameneva��Michael R. Ibbotson��
Hamish Meffin��Veronika Koren��
Timm Lochmann��Valentin Dragoi��Klaus Obermayer��
Maria Psarrou��Maria Schilstra��
Neil Davey��Benjamin Torben-Nielsen��Volker Steuber��	Huiwen Ju��Jiao Yu��Michael L. Hines��
Liang Chen��Yuguo Yu��	Jimin Kim��
Will Leahy��Eli Shlizerman��Justas Birgiolas��Richard C. Gerkin��Sharon M. Crook��Atthaphon Viriyopase��Raoul-Martin Memmesheimer��Stan Gielen��Yuri Dabaghian��
Justin DeVito��Luca Perotti��Anmo J. Kim��Lisa M. Fenk��Cheng Cheng��Gaby Maimon��
Chang Zhao��Yves Widmer��Simon Sprecher��Walter Senn��Geir Halnes��Tuomo Mäki-Marttunen��
Daniel Keller��Klas H. Pettersen��Ole A. Andreassen��Gaute T. Einevoll��Yasunori Yamada��Moira L. Steyn-Ross��D. Alistair Steyn-Ross��Jorge F. Mejias��John D. Murray��
Henry Kennedy��Xiao-Jing Wang��Alexandra Kruscha��	Jan Grewe��	Jan Benda��Benjamin Lindner��
Laurent Badel��Kazumi Ohta��Yoshiko Tsuchimoto��Hokto Kazama��B. Kahng��Nicoladie D. Tam��Luca Pollonini��George Zouridakis��Jaehyun Soh��
DaeEun Kim��	Minsu Yoo��S. E. Palmer��Viviana Culmone��
Ingo Bojak��Andrea Ferrario��Robert Merrison-Hort��Roman Borisyuk��
Chang Sub Kim��Taro Tezuka��
Pangyu Joo��Young-Ah Rho��Shawn D. Burton��G. Bard Ermentrout��Jaeseung Jeong��Nathaniel N. Urban��
Petr Marsalek��Hoon-Hee Kim��Seok-hyun Moon��
Do-won Lee��
Sung-beom Lee��Ji-yong Lee��Yaroslav I. Molkov��Khaldoun Hamade��Wondimu Teka��William H. Barnett��
Taegyo Kim��
Sergey Markin��
Ilya A. Rybak��Csaba Forro��Harald Dermutz��László Demkó��János Vörös��Andrey Babichev��
Haiping Huang��Sergio Verduzco-Flores��Filipa Dos Santos��Peter Andras��Christoph Metzner��Achim Schweikard��Bartosz Zurowski��James P. Roach��Leonard M. Sander��Michal R. Zochowski��Quinton M. Skilling��Nicolette Ognjanovski��Sara J. Aton��Michal Zochowski��Sheng-Jun Wang��Guang Ouyang��
Jing Guang��
Mingsha Zhang��K. Y. Michael Wong��Changsong Zhou��Peter A. Robinson��Paula Sanz-Leon��Peter M. Drysdale��
Felix Fung��Romesh G. Abeysuriya��Chris J. Rennie��Xuelong Zhao��
Yoonsuck Choe��Huei-Fang Yang��Yuanyuan Mi��Xiaohan Lin��Si Wu��Joscha Liedtke��Manuel Schottdorf��	Fred Wolf��Yoriko Yamamura��Jeffery R. Wickens��Timothy Rumbell��Julia Ramsey��	Amy Reyes��Danel Dragulji�Patrick R. Hof��Jennifer Luebke��Christina M. Weaver��Hu He��Xu Yang��	Hailin Ma��
Zhiheng Xu��
Yuzhe Wang��Kwangyeol Baek��Laurel S. Morris��
Prantik Kundu��Valerie Voon��Everton J. Agnes��
Tim P. Vogels��William F. Podlaski��Martin Giese��Pradeep Kuravi��Rufin Vogels��Alexander Seeholzer��William Podlaski��Rajnish Ranjan��
Tim Vogels��Joaquin J. Torres��Fabiano Baroni��Roberto Latorre��	Bart Gips��
Eric Lowet��Mark J. Roberts��Peter de Weerd��
Ole Jensen��Jan van der Eerden��Abdorreza Goodarzinick��Mohammad D. Niry��Alireza Valizadeh��
Aref Pariz��Shervin S. Parsi��Julia M. Warburton��
Lucia Marucci��Francesco Tamagnini��	Jon Brown��Krasimira Tsaneva-Atanasova��Florence I. Kleberg��Jochen Triesch��Bahar Moezzi��Nicolangelo Iannella��Natalie Schaworonkow��Lukas Plogmacher��Mitchell R. Goldsworthy��Brenton Hordacre��Mark D. McDonnell��Michael C. Ridding��Martin Zapotocky��Daniel Smit��Coralie Fouquet��Alain Trembleau��Sakyasingha Dasgupta��Isao Nishikawa��Kazuyuki Aihara��Taro Toyoizumi��Daniel T. Robb��Nick Mellen��Natalia Toporikova��Rongxiang Tang��Yi-Yuan Tang��Guangsheng Liang��
Seth A. Kiser��James H. Howard��Julia Goncharenko��Sergej O. Voronenko��Tosif Ahamed��
Greg Stephens��Pierre Yger��Baptiste Lefebvre��Giulia Lia Beatrice Spampinato��Elric Esposito�� Marcel Stimberg et Olivier Marre��Hansol Choi��Min-Ho Song��
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Dan D. Lee��Haim Sompolinsky��Ryan S. Phillips��
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Dahui Wang��Youngjo Song��Sol Park��Ilhwan Choi��Hee-sup Shin��Hannah Choi��Anitha Pasupathy��Eric Shea-Brown��Dongsung Huh��Terrence J. Sejnowski��
Simon M. Vogt��Arvind Kumar��Robert Schmidt��Stephen Van Wert��Steven J. Schiff��
Richard Veale��Matthias Scheutz��Sang Wan Lee��Júlia Gallinaro��
Stefan Rotter��Leonid L. Rubchinsky��Chung Ching Cheung��#Shivakeshavan Ratnadurai-Giridharan��Safura Rashid Shomali��Majid Nili Ahmadabadi��Hideaki Shimazaki��S. Nader Rasuli��
Xiaochen Zhao��Malte J. Rasch��Jens Wilting��Viola Priesemann��Anna Levina��Lucas Rudelt��Joseph T. Lizier��Richard E. Spinney��Mikail Rubinov��Michael Wibral��Ji Hyun Bak��Jonathan Pillow��	Yuan Zaho��Il Memming Park��Jiyoung Kang��Hae-Jeong Park��Jaeson Jang��Se-Bum Paik��Woochul Choi��Changju Lee��Min Song��Hyeonsu Lee��
Youngjin Park��Ergin Yilmaz��Veli Baysal��Mahmut Ozer��Daniel Saska��Thomas Nowotny��
Ho Ka Chan��Alan Diamond��Christoph S. Herrmann��Micah M. Murray��Silvio Ionta��	Axel Hutt��Jérémie Lefebvre��Philipp Weidel��
Renato Duarte��Abigail Morrison��Jung H. Lee��Ramakrishnan Iyer��Stefan Mihalas��
Christof Koch��Mihai A. Petrovici��Luziwei Leng��Oliver Breitwieser��David Stöckel��
Ilja Bytschok��Roman Martel��
Johannes Bill��Johannes Schemmel��Karlheinz Meier��Timothy B. Esler��Anthony N. Burkitt��Robert R. Kerr��Bahman Tahayori��	Max Nolte��Michael W. Reimann��Eilif Muller��
Henry Markram��Antonio Parziale��
Rosa Senatore��Angelo Marcelli��	K. Skiker��
M. Maouene��Samuel A. Neymotin��Alexandra Seidenstein��
Peter Lakatos��Terence D. Sanger��Rosemary J. Menzies��Campbell McLauchlan��Sacha J. van Albada��David J. Kedziora��Samuel Neymotin��
Cliff C. Kerr��Benjamin A. Suter��Gordon M. G. Shepherd��Juhyoung Ryu��Sang-Hun Lee��Joonwon Lee��Hyang Jung Lee��Daeseob Lim��Jisung Wang��Heonsoo Lee��Nam Jung��Le Anh Quang��Seung Eun Maeng��
Tae Ho Lee��Jae Woo Lee��Chang-hyun Park��Sora Ahn��Jangsup Moon��Yun Seo Choi��	Juhee Kim��
Sang Beom Jun��Seungjun Lee��Hyang Woon Lee��Sumin Jo��	Eunji Jun��Suin Yu��Felix Goetze��Pik-Yin Lai��
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Ramon Reig��
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Jae-Hwan Kang��Chungho Lee��Andreas Spiegler��Spase Petkoski��Matias J. Palva��Viktor K. Jirsa��Maria L. Saggio��Silvan F. Siep��William C. Stacey��Christophe Bernar��Oh-hyeon Choung��
Yong Jeong��Yong-il Lee��Su Hyun Kim��	Mir Jeong��Jeungmin Lee��
Jaehyung Kwon��Jerald D. Kralik��
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Dong-Uk Hwang��Jae-Hyung Kwon��
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Seongkyun Kim��
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Thomas Miller��Katie Clements��Sungwoo Ahn��Eoon Hye Ji��Fadi A. Issa��
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Shigeyuki Oba��Junichiro Yoshimoto��
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Shin Ishii��Thiago S. Mosqueiro��Martin F. Strube-Bloss��Brian Smith��Ramon Huerta��Michal Hadrava��Jaroslav Hlinka��
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René Richter��Julien Vitay��Frederick Beuth��Fred H. Hamker��Kelly Toppin��	Yixin Guo��Bruce P. Graham��Penelope J. Kale��Leonardo L. Gollo��Merav Stern��L. F. Abbott��Leonid A. Fedorov��Martin A. Giese��Mohammad Hovaidi Ardestani��Mohammad Javad Faraji��Kerstin Preuschoff��Wulfram Gerstner��Margriet J. van Gendt��Jeroen J. Briaire��Randy K. Kalkman��Johan H. M. Frijns��Won Hee Lee��Sophia Frangou��Ben D. Fulcher��Patricia H. P. Tran��Alex Fornito��Stephen V. Gliske��
Eugene Lim��Katherine A. Holman��Christian G. Fink��Jinseop S. Kim��Shang Mu��Kevin L. Briggman��H. Sebastian Seung��Detlef Wegener��Lisa Bohnenkamp��Udo A. Ernst��
Anna Devor��Anders M. Dale��Glenn T. Lines��Andy Edwards��Aslak Tveito��Espen Hagen��Johanna Senk��Markus Diesmann��Maximilian Schmidt��Rembrandt Bakker��
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Weiliang Chen��
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Yoon-Kyu Song��Frédéric Chavane��
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LieJune Shiau��Laure Buhry��Kanishka Basnayake��Sue-Hyun Lee��Brandon A. Levy��Chris I. Baker��Timothée Leleu��Ryan T. Philips��Karishma Chhabria�eh
�BMC neuroscience�h�2016-Aug�hXzA1 Functional advantages of cell-type heterogeneity in neural circuits Tatyana O. Sharpee A2 Mesoscopic modeling of propagating waves in visual cortex Alain Destexhe A3 Dynamics and biomarkers of mental disorders Mitsuo Kawato F1 Precise recruitment of spiking output at theta frequencies requires dendritic h-channels in multi-compartment models of oriens-lacunosum/moleculare hippocampal interneurons Vladislav Sekulić, Frances K. Skinner F2 Kernel methods in reconstruction of current sources from extracellular potentials for single cells and the whole brains Daniel K. Wójcik, Chaitanya Chintaluri, Dorottya Cserpán, Zoltán Somogyvári F3 The synchronized periods depend on intracellular transcriptional repression mechanisms in circadian clocks. Jae Kyoung Kim, Zachary P. Kilpatrick, Matthew R. Bennett, Kresimir Josić O1 Assessing irregularity and coordination of spiking-bursting rhythms in central pattern generators Irene Elices, David Arroyo, Rafael Levi, Francisco B. Rodriguez, Pablo Varona O2 Regulation of top-down processing by cortically-projecting parvalbumin positive neurons in basal forebrain Eunjin Hwang, Bowon Kim, Hio-Been Han, Tae Kim, James T. McKenna, Ritchie E. Brown, Robert W. McCarley, Jee Hyun Choi O3 Modeling auditory stream segregation, build-up and bistability James Rankin, Pamela Osborn Popp, John Rinzel O4 Strong competition between tonotopic neural ensembles explains pitch-related dynamics of auditory cortex evoked fields Alejandro Tabas, André Rupp, Emili Balaguer-Ballester O5 A simple model of retinal response to multi-electrode stimulation Matias I. Maturana, David B. Grayden, Shaun L. Cloherty, Tatiana Kameneva, Michael R. Ibbotson, Hamish Meffin O6 Noise correlations in V4 area correlate with behavioral performance in visual discrimination task Veronika Koren, Timm Lochmann, Valentin Dragoi, Klaus Obermayer O7 Input-location dependent gain modulation in cerebellar nucleus neurons Maria Psarrou, Maria Schilstra, Neil Davey, Benjamin Torben-Nielsen, Volker Steuber O8 Analytic solution of cable energy function for cortical axons and dendrites Huiwen Ju, Jiao Yu, Michael L. Hines, Liang Chen, Yuguo Yu O9 �h�10.1186/s12868-016-0283-6�h]�ues�expires��datetime��datetime���C
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