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# Chat Transcript: PFOA Contamination in Drinking Water Analysis ## Analyzing PFOA Concentrations Using SPOKE-OKN Knowledge Graph 👤 **User** @spoke-okn: get the top 3 locations where PFOA has the highest concentration in drinking water --- 🧠 **Assistant** Based on the SPOKE-OKN knowledge graph data, I found the **top 3 locations with the highest PFOA concentrations in drinking water**: ### Top 3 Locations: 1. **ZIP Code 19426, Pennsylvania** - Concentration: 0.235 µg/L (with detection limit of 0.004 µg/L) - This is the highest concentration found 2. **ZIP Code 26106, West Virginia** - Concentration: 0.0465 µg/L (with detection limit of 0.004 µg/L) - Multiple ZIP codes in West Virginia showed this same concentration level 3. **ZIP Code 85541, Arizona** - Concentration: 0.0409 µg/L (with detection limit of 0.004 µg/L) ### Key Details: - **Data source**: UCMR5 (Fifth Unregulated Contaminant Monitoring Rule) - **Measurement type**: Maximum Concentration (with Minimum Reporting Level) - **Units**: µg/L (micrograms per liter) ### Analysis: The Pennsylvania location (ZIP 19426) shows a notably higher PFOA concentration - about 5 times higher than the second-highest locations in West Virginia. PFOA is a perfluorooctanoic acid, one of the persistent "forever chemicals" (PFAS) that have raised significant public health concerns. ### Technical Query Details: The analysis involved querying the SPOKE-OKN knowledge graph, which integrates: - Biomedical and environmental health data - Geographic information (from countries to ZIP codes) - Chemical compounds and their environmental presence - Social determinants of health The query specifically searched for: - PFOA compound (Perfluorooctanoic acid - PubChem InChIKey: SNGREZUHAYWORS-UHFFFAOYSA-N) - Relationships indicating chemical presence in locations (FOUNDIN_CfL) - Media type filtered to "Drinking Water" - Sorted by concentration values to identify the highest levels ### Data Insights: - Total PFOA drinking water measurements: 1,721 locations - Data represents the Fifth Unregulated Contaminant Monitoring Rule (UCMR5) testing - Measurements include both the detected concentration and the minimum reporting level (in parentheses) - The pattern shows concentrated areas of concern in PA, WV, and AZ --- *Created by [mcp-proto-okn](https://github.com/sbl-sdsc/mcp-proto-okn) on 2025-12-17*

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