OpenGenes MCP Server

What genes need to be downregulated in worms to extend their lifespan? What processes are improved in GHR knockout mice? Which genetic intervention led to the greatest increase in lifespan in flies? To what extent did the lifespan increase in mice overexpressing VEGFA? Are there any liver-specific interventions that increase lifespan in mice? Which gene-longevity association is confirmed by the greatest number of studies? What polymorphisms in FOXO3 are associated with human longevity? In which ethnic groups was the association of the APOE gene with longevity shown? Is the INS gene polymorphism associated with longevity? What genes are associated with transcriptional alterations? Which hallmarks are associated with the KL gene? What genes change their expression with aging in humans? How many genes are associated with longevity in humans? What types of studies have been conducted on the IGF1R gene? What evidence of the link between PTEN and aging do you know? What genes are associated with both longevity and altered expression in aged humans? Is the expression of the ACE2 gene altered with aging in humans? Interventions on which genes extended mice lifespan most of all? Which knockdowns were most lifespan extending on model animals?