- id: lab-1
date: 2023-12-15
test_name: Complete Blood Count
ordering_provider: Dr. Patricia Williams
results:
- component: WBC
value: "8.2"
unit: K/uL
reference_range: 4.5-11.0
status: normal
- component: Hemoglobin
value: "11.5"
unit: g/dL
reference_range: 13.5-17.5
status: low
- component: Platelets
value: "285"
unit: K/uL
reference_range: 150-400
status: normal
- id: lab-2
date: 2023-12-15
test_name: Comprehensive Metabolic Panel
ordering_provider: Dr. Patricia Williams
results:
- component: Glucose
value: "95"
unit: mg/dL
reference_range: 70-100
status: normal
- component: Creatinine
value: "0.9"
unit: mg/dL
reference_range: 0.7-1.3
status: normal
- component: ALT
value: "32"
unit: U/L
reference_range: 7-56
status: normal
- component: AST
value: "28"
unit: U/L
reference_range: 10-40
status: normal
- component: Albumin
value: "3.8"
unit: g/dL
reference_range: 3.5-5.0
status: normal
- id: lab-3
date: 2024-03-20
test_name: Tumor Markers
ordering_provider: Dr. Michael Anderson
results:
- component: CEA
value: "185"
unit: ng/mL
reference_range: <3.0
status: high
- component: CA 19-9
value: "125"
unit: U/mL
reference_range: <37
status: high
- id: lab-4
date: 2024-05-20
test_name: Complete Blood Count
ordering_provider: Dr. Michael Anderson
results:
- component: WBC
value: "4.2"
unit: K/uL
reference_range: 4.5-11.0
status: low
- component: Hemoglobin
value: "11.2"
unit: g/dL
reference_range: 13.5-17.5
status: low
- component: Platelets
value: "185"
unit: K/uL
reference_range: 150-400
status: normal
- component: ANC
value: "2.8"
unit: K/uL
reference_range: ">1.5"
status: normal
- id: lab-5
date: 2024-05-20
test_name: Comprehensive Metabolic Panel
ordering_provider: Dr. Michael Anderson
results:
- component: Creatinine
value: "0.8"
unit: mg/dL
reference_range: 0.7-1.3
status: normal
- component: ALT
value: "45"
unit: U/L
reference_range: 7-56
status: normal
- component: AST
value: "38"
unit: U/L
reference_range: 10-40
status: normal
- component: Total Bilirubin
value: "0.9"
unit: mg/dL
reference_range: 0.3-1.2
status: normal
- id: lab-6
date: 2024-05-20
test_name: Tumor Markers
ordering_provider: Dr. Michael Anderson
results:
- component: CEA
value: "95"
unit: ng/mL
reference_range: <3.0
status: high
- id: lab-7
date: 2024-07-15
test_name: Complete Blood Count
ordering_provider: Dr. Michael Anderson
results:
- component: WBC
value: "5.5"
unit: K/uL
reference_range: 4.5-11.0
status: normal
- component: Hemoglobin
value: "12.1"
unit: g/dL
reference_range: 13.5-17.5
status: low
- component: Platelets
value: "225"
unit: K/uL
reference_range: 150-400
status: normal
- id: lab-8
date: 2024-07-15
test_name: Tumor Markers
ordering_provider: Dr. Michael Anderson
results:
- component: CEA
value: "42"
unit: ng/mL
reference_range: <3.0
status: high
- id: lab-9
date: 2024-09-10
test_name: Complete Blood Count
ordering_provider: Dr. Michael Anderson
results:
- component: WBC
value: "6.2"
unit: K/uL
reference_range: 4.5-11.0
status: normal
- component: Hemoglobin
value: "12.8"
unit: g/dL
reference_range: 13.5-17.5
status: low
- component: Platelets
value: "242"
unit: K/uL
reference_range: 150-400
status: normal
- id: lab-10
date: 2024-09-10
test_name: Tumor Markers
ordering_provider: Dr. Michael Anderson
results:
- component: CEA
value: "38"
unit: ng/mL
reference_range: <3.0
status: high
- id: lab-11
date: 2024-10-15
test_name: Comprehensive Metabolic Panel
ordering_provider: Dr. Michael Anderson
results:
- component: Sodium
value: "138"
unit: mmol/L
reference_range: 136-145
status: normal
- component: Potassium
value: "4.2"
unit: mmol/L
reference_range: 3.5-5.0
status: normal
- component: Creatinine
value: "0.9"
unit: mg/dL
reference_range: 0.7-1.3
status: normal
- component: ALT
value: "68"
unit: U/L
reference_range: 7-56
status: high
- component: AST
value: "72"
unit: U/L
reference_range: 10-40
status: high
- component: Alkaline Phosphatase
value: "185"
unit: U/L
reference_range: 40-130
status: high
- component: Total Bilirubin
value: "1.5"
unit: mg/dL
reference_range: 0.3-1.2
status: high
- component: Albumin
value: "3.2"
unit: g/dL
reference_range: 3.5-5.0
status: low
- id: lab-12
date: 2024-11-18
test_name: Complete Blood Count
ordering_provider: Dr. Michael Anderson
results:
- component: WBC
value: "5.8"
unit: K/uL
reference_range: 4.5-11.0
status: normal
- component: Hemoglobin
value: "10.8"
unit: g/dL
reference_range: 13.5-17.5
status: low
- component: Platelets
value: "198"
unit: K/uL
reference_range: 150-400
status: normal
- component: ANC
value: "3.2"
unit: K/uL
reference_range: ">1.5"
status: normal
- id: lab-13
date: 2024-11-18
test_name: Tumor Markers
ordering_provider: Dr. Michael Anderson
results:
- component: CEA
value: "125"
unit: ng/mL
reference_range: <3.0
status: high
- component: CA 19-9
value: "245"
unit: U/mL
reference_range: <37
status: high
- id: lab-14
date: 2024-11-20
test_name: Molecular Testing
ordering_provider: Dr. Michael Anderson
results:
- component: KRAS Status
value: "Wild-type"
unit: ""
reference_range: ""
status: normal
- component: NRAS Status
value: "Wild-type"
unit: ""
reference_range: ""
status: normal
- component: BRAF V600E
value: "Not detected"
unit: ""
reference_range: ""
status: normal
- component: MSI Status
value: "MSS (Microsatellite Stable)"
unit: ""
reference_range: ""
status: normal
- id: lab-15
date: 2024-12-10
test_name: Complete Blood Count
ordering_provider: Dr. Michael Anderson
results:
- component: WBC
value: "4.8"
unit: K/uL
reference_range: 4.5-11.0
status: normal
- component: Hemoglobin
value: "10.2"
unit: g/dL
reference_range: 13.5-17.5
status: low
- component: Platelets
value: "175"
unit: K/uL
reference_range: 150-400
status: normal
- id: lab-16
date: 2024-12-15
test_name: Coagulation Panel
ordering_provider: Dr. Michael Anderson
results:
- component: PT
value: "13.2"
unit: seconds
reference_range: 11.0-13.5
status: normal
- component: INR
value: "1.1"
unit: ""
reference_range: 0.8-1.2
status: normal
- component: PTT
value: "28"
unit: seconds
reference_range: 25-35
status: normal
- id: lab-17
date: 2024-01-18
test_name: Surgical Pathology
ordering_provider: Dr. James Martinez
results:
- component: Specimen Type
value: "Colon biopsy, sigmoid"
unit: ""
reference_range: ""
status: normal
- component: Diagnosis
value: "Invasive moderately differentiated adenocarcinoma"
unit: ""
reference_range: ""
status: abnormal
- component: Lymphovascular Invasion
value: "Present"
unit: ""
reference_range: "Absent"
status: abnormal
- component: MSI Status
value: "Microsatellite Stable (MSS)"
unit: ""
reference_range: ""
status: normal
report: |
SPRINGFIELD PATHOLOGY ASSOCIATES
Surgical Pathology Report
Patient: Robert Chen
MRN: MRN003
Date of Procedure: January 15, 2024
Date of Report: January 18, 2024
Specimen: Colon biopsy, sigmoid
CLINICAL HISTORY:
56-year-old male with rectal bleeding, change in bowel habits, and sigmoid mass
seen on colonoscopy.
GROSS DESCRIPTION:
Received in formalin labeled "sigmoid colon biopsy" are six fragments of tan-pink
tissue ranging from 0.2 to 0.4 cm in greatest dimension. All tissue submitted in
two cassettes.
MICROSCOPIC DESCRIPTION:
Sections show colonic mucosa with an invasive adenocarcinoma. The tumor is
moderately differentiated and consists of malignant glands infiltrating through
the muscularis mucosae into the submucosa. There is associated desmoplastic
stromal reaction and lymphovascular space invasion is identified.
The malignant glands show enlarged, hyperchromatic nuclei with prominent nucleoli
and increased mitotic activity. Areas of necrosis are present.
IMMUNOHISTOCHEMISTRY:
CK20: Positive
CDX2: Positive
CK7: Negative
MLH1: Retained nuclear expression
MSH2: Retained nuclear expression
MSH6: Retained nuclear expression
PMS2: Retained nuclear expression
MOLECULAR:
Microsatellite instability testing: Microsatellite stable (MSS)
DIAGNOSIS:
SIGMOID COLON, BIOPSY:
- INVASIVE MODERATELY DIFFERENTIATED ADENOCARCINOMA
- LYMPHOVASCULAR INVASION PRESENT
- TUMOR IS MICROSATELLITE STABLE
COMMENT:
This is a conventional colonic adenocarcinoma. Retained expression of mismatch
repair proteins (MLH1, MSH2, MSH6, PMS2) indicates microsatellite stable tumor.
Clinical correlation and staging studies recommended to determine extent of disease
and guide treatment decisions.
Pathologist: Dr. Elizabeth Morgan, MD
Board Certified Anatomic and Clinical Pathology
Date Signed: January 18, 2024
- id: lab-18
date: 2024-11-25
test_name: Cytopathology
ordering_provider: Dr. Sarah Thompson
results:
- component: Specimen Type
value: "Peritoneal fluid (ascites)"
unit: ""
reference_range: ""
status: normal
- component: Cytology
value: "Positive for malignant cells"
unit: ""
reference_range: "Negative"
status: abnormal
- component: Cell Type
value: "Metastatic adenocarcinoma"
unit: ""
reference_range: ""
status: abnormal
- component: SAAG
value: "0.8"
unit: g/dL
reference_range: ">1.1 (transudative)"
status: abnormal
report: |
SPRINGFIELD CYTOLOGY LABORATORY
Fluid Cytology Report
Patient: Robert Chen
MRN: MRN003
Date of Procedure: November 22, 2024
Date of Report: November 25, 2024
Specimen: Peritoneal fluid (ascites)
CLINICAL HISTORY:
56-year-old male with metastatic colorectal cancer on chemotherapy. New-onset
ascites identified on recent CT imaging. Diagnostic paracentesis performed.
GROSS DESCRIPTION:
Received 500 mL of straw-colored, slightly turbid peritoneal fluid in sterile
container. Fluid processed for cytological examination and cell block preparation.
MICROSCOPIC DESCRIPTION:
Cytospin preparations and cell block sections show numerous three-dimensional
clusters and sheets of malignant epithelial cells in a background of mesothelial
cells, lymphocytes, and macrophages.
The malignant cells display:
- Enlarged hyperchromatic nuclei with irregular nuclear contours
- Prominent nucleoli
- Increased nuclear to cytoplasmic ratio
- Moderate eosinophilic cytoplasm
- Occasional glandular/acinar formation
Background shows reactive mesothelial cells with no evidence of atypia.
No microorganisms identified on Gram stain.
IMMUNOHISTOCHEMISTRY (Cell Block):
CK20: Positive (diffuse)
CDX2: Positive
CK7: Negative
Calretinin: Negative in malignant cells (positive in mesothelial cells)
CEA: Positive
The immunophenotype is consistent with colonic/lower GI tract origin.
DIAGNOSIS:
PERITONEAL FLUID, PARACENTESIS:
- POSITIVE FOR MALIGNANT CELLS
- CONSISTENT WITH METASTATIC ADENOCARCINOMA
- MORPHOLOGY AND IMMUNOPROFILE COMPATIBLE WITH COLORECTAL PRIMARY
COMMENT:
The cytologic findings confirm malignant ascites in this patient with known
metastatic colorectal carcinoma. The presence of tumor cells in peritoneal
fluid indicates peritoneal involvement, though no discrete peritoneal masses
were identified on recent CT imaging. This represents disease progression.
Clinical correlation is recommended regarding adjustment of systemic therapy.
FLUID ANALYSIS (sent to Chemistry):
Total Protein: 3.8 g/dL (elevated)
LDH: 285 U/L (elevated)
Serum-Ascites Albumin Gradient (SAAG): 0.8 g/dL (exudative)
Cell Count: 1,850 WBC/μL (elevated)
Findings consistent with malignant (exudative) ascites.
Cytopathologist: Dr. Elizabeth Morgan, MD
Board Certified Anatomic and Clinical Pathology
Date Signed: November 25, 2024