Uses GraphQL queries to efficiently retrieve data from the Open Targets platform API
Displays API version badges for the Open Targets platform integration
Unofficial Open Targets MCP Server 🧬
Unofficial Model Context Protocol server for accessing Open Targets platform data for gene-drug-disease associations research.
Developed by Augmented Nature
✅ Verified Features
All 6 tools working with live Open Targets API data:
- 🎯 Target Search - Gene symbols, names, descriptions (BRCA1, TP53, etc.)
- 🦠 Disease Search - Names, synonyms, descriptions (cancer, diabetes, etc.)
- 🔗 Target-Disease Associations - Evidence scores from 20+ databases
- 📊 Disease Target Summaries - Prioritized therapeutic targets
- 🧬 Target Details - Comprehensive gene/protein information
- 🎭 Disease Details - Complete disease profiles with ontologies
🚀 Quick Start
📋 MCP Client Configuration
Claude Desktop
Other MCP Clients
🛠️ Available Tools
🎯 search_targets
Search therapeutic targets by gene symbol, name, or description
Example Results:
- BRCA1 (ENSG00000012048) - BRCA1 DNA repair associated
- BRCA2 (ENSG00000139618) - BRCA2 DNA repair associated
- BRIP1 (ENSG00000136492) - BRCA1 interacting DNA helicase 1
🦠 search_diseases
Search diseases by name, synonym, or description
🔗 get_target_disease_associations
Get target-disease associations with evidence scores
OR
📊 get_disease_targets_summary
Get prioritized targets associated with a disease
🧬 get_target_details
Get comprehensive target information
🎭 get_disease_details
Get comprehensive disease information
📚 Resource Templates
Access Open Targets data through standardized URIs:
opentargets://target/{ensemblId}
- Complete target informationopentargets://disease/{efoId}
- Complete disease informationopentargets://drug/{chemblId}
- Drug informationopentargets://association/{targetId}/{diseaseId}
- Association evidenceopentargets://search/{query}
- Search results
🧪 Real-World Examples
Cancer Research Workflow
Drug Discovery Pipeline
🔬 Data Sources & Standards
Open Targets integrates 20+ databases:
- ChEMBL - Drug & compound data
- Ensembl - Gene & protein annotations
- EFO - Experimental Factor Ontology
- ClinVar - Clinical variant data
- GWAS Catalog - Genome-wide association studies
- UniProt - Protein sequences & functions
- Reactome - Biological pathways
- And many more...
Standardized Identifiers:
- Targets: Ensembl gene IDs (e.g., ENSG00000012048)
- Diseases: EFO IDs (e.g., EFO_0000305)
- Drugs: ChEMBL IDs (e.g., CHEMBL1234)
🏗️ Architecture
- TypeScript implementation with robust type safety
- GraphQL queries for efficient data retrieval
- MCP Protocol compliant JSON-RPC communication
- Error Handling with comprehensive validation
- Production Ready with 30s timeouts and proper logging
📊 API Information
- Base URL:
https://api.platform.opentargets.org/api/v4/graphql
- Version: Open Targets v25.0.1
- Rate Limits: Generous for research use
- Authentication: None required
- Format: GraphQL queries, JSON responses
🤝 Contributing
This server is developed and maintained by Augmented Nature. For enhancements:
- Fork the repository
- Make your changes
- Submit a pull request
Support
For issues with:
- MCP Server: Check the server logs and error outputs
- Open Targets API: Visit platform.opentargets.org
- GraphQL Queries: Use the Open Targets GraphQL browser
Citation
If you use this project in your research or publications, please cite it as follows:
This server cannot be installed
Unofficial Model Context Protocol server for accessing Open Targets platform data for gene-drug-disease associations research.
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