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Guidetopharmacology

by io.github.pipeworx-io
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Target Interactions

target_interactions
Read-onlyIdempotent

List the quantitative ligand interactions for a protein target in the Guide to PHARMACOLOGY (IUPHAR/BPS). Given a GtoPdb target id (from search_targets), returns the ligands acting on it with interaction type (Agonist/Antagonist/Inhibitor/etc.), action, and binding affinity (e.g. pKi/pIC50). Requires a GtoPdb API key — register free at guidetopharmacology.org/login.jsp and pass your own via _apiKey.

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
limitNoMax interactions to return (default 25).
target_idYesGtoPdb target id, e.g. 1797 for EGFR.

Schema Changelog

Changes observed during successful MCP inspections.

  1. Changed1 schema field changed
    • changedInput schema / examples
      Previous value: -[
-  {
-    "target_id": 1797
-  },
-  {
-    "limit": 50,
-    "target_id": "1797"
-  }
-]New value: +[
+  {
+    "_apiKey": "your-guidetopharmacology-api-key",
+    "target_id": 1797
+  },
+  {
+    "_apiKey": "your-guidetopharmacology-api-key",
+    "limit": 50,
+    "target_id": "1797"
+  }
+]
  2. Changed1 schema field changed
    • addedInput schema / examples
      Added value: +[
+  {
+    "target_id": 1797
+  },
+  {
+    "limit": 50,
+    "target_id": "1797"
+  }
+]
  3. First observed

TDQS

Score is being calculated.

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