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Jean — Molecular Biology & Genomics

query_database

Read-only

Ask one of the ~60 authoritative databases a question and hand its rows downstream — Ensembl, UniProt, ClinVar, gnomAD, ChEMBL, PubChem, InterPro, STRING, PDB, AlphaFold, the GWAS Catalog, PubMed and the rest.

Input Schema

NameRequiredDescriptionDefault
limitNocap on rows returned, where the authority honours one.
queryYeswhat to ask, in the authority's own terms — an identifier, a gene symbol, or one of its command forms such as `ensembl_lookup:BRCA2`.
_filesNoThe project: record references shaped like _subject. Their records become library documents a tool names in sequences/parts/document; a trace or alignment is found by file name.
_subjectNoThe record to act on: exactly one of sequence, accession (+source), sample (an id from list_samples) or file ({name, text} or {name, base64}); record_index picks one record of several.
authorityYeswhich database to ask. Values: pubmed (NCBI PubMed (E-utilities) — literature), pmc-idconv (NCBI PMC ID Converter — literature), europepmc (Europe PMC — literature), openalex (OpenAlex — literature), crossref (Crossref — literature), arxiv (arXiv — literature), biorxiv (bioRxiv — literature), medrxiv (medRxiv — literature), datacite (DataCite — literature), ensembl (Ensembl REST — genomics), ucsc (UCSC Genome Browser API — genomics), biomart (Ensembl BioMart — genomics), mygene (MyGene.info — genomics), ncbi-gene (NCBI Gene (E-utilities) — genomics), hgnc (HGNC (genenames.org) — genomics), gnomad (gnomAD (Broad) — genomics), clinvar (NCBI ClinVar — genomics), dbsnp (NCBI dbSNP — genomics), variation (NCBI Variation Services — genomics), cadd (CADD (Kircher lab) — genomics), gtex (GTEx Portal — genomics), eqtlcatalogue (eQTL Catalogue (EBI) — genomics), gwascatalog (GWAS Catalog (EBI/NHGRI) — genomics), pheweb (PheWeb / FinnGen — genomics), uniprot (UniProt — proteins), interpro (InterPro / Pfam (EBI) — proteins), string (STRING — proteins), proteinatlas (Human Protein Atlas — proteins), alphafold (AlphaFold DB (EBI) — proteins), pdb (RCSB PDB — proteins), emdb (EMDB (EBI) — proteins), complexportal (Complex Portal (EBI) — proteins), intact (IntAct (EBI) — proteins), chembl (ChEMBL (EBI) — chemistry), pubchem (PubChem (NCBI) — chemistry), chebi (ChEBI (EBI) — chemistry), bindingdb (BindingDB — chemistry), zinc (ZINC (CartBlanche, UCSF) — chemistry), rhea (Rhea (EBI) — chemistry), clinicaltrials (ClinicalTrials.gov — clinical), openfda (openFDA — clinical), opentargets (Open Targets Platform — clinical), civic (CIViC — clinical), clingen (ClinGen (erepo.genome.network) — clinical), cosmic (COSMIC via NLM Clinical Tables — clinical), depmap (Cell Model Passports (Sanger) — clinical), cbioportal (cBioPortal — clinical), geo (NCBI GEO — omics), arrayexpress (ArrayExpress / BioStudies (EBI) — omics), pride (PRIDE (EBI) — omics), metabolights (MetaboLights (EBI) — omics), mgnify (MGnify (EBI) — omics), encode (ENCODE Project — omics), jaspar (JASPAR (Elixir) — omics), unibind (UniBind (Univ. of Oslo) — omics), cellguide (CellGuide (CZI CELLxGENE) — cells), panglaodb (PanglaoDB — cells), antibodyregistry (Antibody Registry (RRID) — cells), ols (OLS4 (EBI) — ontology), quickgo (QuickGO (EBI) — ontology), identifiers-org (identifiers.org registry — ontology), ncbi-taxonomy (NCBI Taxonomy (E-utilities) — ontology), reactome (Reactome — ontology), kegg (KEGG — ontology), rfam (Rfam (EBI) — ontology), grantsgov (Grants.gov — funding).

Output Schema

NameRequiredDescriptionDefault
countYeshow many rows came back
resultsYesthe rows the authority returned — wire into filter_items, check_rows or summarize_rows
envelopeYesthe whole response, for a row shape this node's `results` does not name
authorityYeswhich authority answered, stated rather than implied
endpointsYesthe URLs actually called — the provenance a methods section needs
retrievedAtYeswhen it was fetched, because a live lookup is a fact about a moment

Schema Changelog

Changes observed during successful MCP inspections.

  1. Changed1 schema field changed
    • addedInput schema / properties / limit / default
      Added value: +10
  2. Changed2 schema fields changed
    • changedInput schema / properties / authority / description
      Previous value: -"which database to ask. Values: pubmed (NCBI PubMed (E-utilities) — literature), pmc-idconv (NCBI PMC ID Converter — literature), europepmc (Europe PMC — literature), openalex (OpenAlex — literature), crossref (Crossref — literature), arxiv (arXiv — literature), biorxiv (bioRxiv — literature), medrxiv (medRxiv — literature), datacite (DataCite — literature), ensembl (Ensembl REST — genomics), ucsc (UCSC Genome Browser API — genomics), biomart (Ensembl BioMart — genomics), mygene (MyGene.info — genomics), gnomad (gnomAD (Broad) — genomics), clinvar (NCBI ClinVar — genomics), dbsnp (NCBI dbSNP — genomics), variation (NCBI Variation Services — genomics), cadd (CADD (Kircher lab) — genomics), gtex (GTEx Portal — genomics), eqtlcatalogue (eQTL Catalogue (EBI) — genomics), gwascatalog (GWAS Catalog (EBI/NHGRI) — genomics), pheweb (PheWeb / FinnGen — genomics), uniprot (UniProt — proteins), interpro (InterPro / Pfam (EBI) — proteins), string (STRING — proteins), proteinatlas (Human Protein Atlas — proteins), alphafold (AlphaFold DB (EBI) — proteins), pdb (RCSB PDB — proteins), emdb (EMDB (EBI) — proteins), complexportal (Complex Portal (EBI) — proteins), intact (IntAct (EBI) — proteins), chembl (ChEMBL (EBI) — chemistry), pubchem (PubChem (NCBI) — chemistry), chebi (ChEBI (EBI) — chemistry), bindingdb (BindingDB — chemistry), zinc (ZINC (CartBlanche, UCSF) — chemistry), rhea (Rhea (EBI) — chemistry), clinicaltrials (ClinicalTrials.gov — clinical), openfda (openFDA — clinical), opentargets (Open Targets Platform — clinical), civic (CIViC — clinical), clingen (ClinGen (erepo.genome.network) — clinical), cosmic (COSMIC via NLM Clinical Tables — clinical), depmap (Cell Model Passports (Sanger) — clinical), cbioportal (cBioPortal — clinical), geo (NCBI GEO — omics), arrayexpress (ArrayExpress / BioStudies (EBI) — omics), pride (PRIDE (EBI) — omics), metabolights (MetaboLights (EBI) — omics), mgnify (MGnify (EBI) — omics), encode (ENCODE Project — omics), jaspar (JASPAR (Elixir) — omics), unibind (UniBind (Univ. of Oslo) — omics), cellguide (CellGuide (CZI CELLxGENE) — cells), panglaodb (PanglaoDB — cells), antibodyregistry (Antibody Registry (RRID) — cells), ols (OLS4 (EBI) — ontology), quickgo (QuickGO (EBI) — ontology), reactome (Reactome — ontology), kegg (KEGG — ontology), rfam (Rfam (EBI) — ontology), grantsgov (Grants.gov — funding)."New value: +"which database to ask. Values: pubmed (NCBI PubMed (E-utilities) — literature), pmc-idconv (NCBI PMC ID Converter — literature), europepmc (Europe PMC — literature), openalex (OpenAlex — literature), crossref (Crossref — literature), arxiv (arXiv — literature), biorxiv (bioRxiv — literature), medrxiv (medRxiv — literature), datacite (DataCite — literature), ensembl (Ensembl REST — genomics), ucsc (UCSC Genome Browser API — genomics), biomart (Ensembl BioMart — genomics), mygene (MyGene.info — genomics), ncbi-gene (NCBI Gene (E-utilities) — genomics), hgnc (HGNC (genenames.org) — genomics), gnomad (gnomAD (Broad) — genomics), clinvar (NCBI ClinVar — genomics), dbsnp (NCBI dbSNP — genomics), variation (NCBI Variation Services — genomics), cadd (CADD (Kircher lab) — genomics), gtex (GTEx Portal — genomics), eqtlcatalogue (eQTL Catalogue (EBI) — genomics), gwascatalog (GWAS Catalog (EBI/NHGRI) — genomics), pheweb (PheWeb / FinnGen — genomics), uniprot (UniProt — proteins), interpro (InterPro / Pfam (EBI) — proteins), string (STRING — proteins), proteinatlas (Human Protein Atlas — proteins), alphafold (AlphaFold DB (EBI) — proteins), pdb (RCSB PDB — proteins), emdb (EMDB (EBI) — proteins), complexportal (Complex Portal (EBI) — proteins), intact (IntAct (EBI) — proteins), chembl (ChEMBL (EBI) — chemistry), pubchem (PubChem (NCBI) — chemistry), chebi (ChEBI (EBI) — chemistry), bindingdb (BindingDB — chemistry), zinc (ZINC (CartBlanche, UCSF) — chemistry), rhea (Rhea (EBI) — chemistry), clinicaltrials (ClinicalTrials.gov — clinical), openfda (openFDA — clinical), opentargets (Open Targets Platform — clinical), civic (CIViC — clinical), clingen (ClinGen (erepo.genome.network) — clinical), cosmic (COSMIC via NLM Clinical Tables — clinical), depmap (Cell Model Passports (Sanger) — clinical), cbioportal (cBioPortal — clinical), geo (NCBI GEO — omics), arrayexpress (ArrayExpress / BioStudies (EBI) — omics), pride (PRIDE (EBI) — omics), metabolights (MetaboLights (EBI) — omics), mgnify (MGnify (EBI) — omics), encode (ENCODE Project — omics), jaspar (JASPAR (Elixir) — omics), unibind (UniBind (Univ. of Oslo) — omics), cellguide (CellGuide (CZI CELLxGENE) — cells), panglaodb (PanglaoDB — cells), antibodyregistry (Antibody Registry (RRID) — cells), ols (OLS4 (EBI) — ontology), quickgo (QuickGO (EBI) — ontology), identifiers-org (identifiers.org registry — ontology), ncbi-taxonomy (NCBI Taxonomy (E-utilities) — ontology), reactome (Reactome — ontology), kegg (KEGG — ontology), rfam (Rfam (EBI) — ontology), grantsgov (Grants.gov — funding)."
    • changedInput schema / properties / authority / enum
      Previous value: -[
      -  "pubmed",
      -  "pmc-idconv",
      -  "europepmc",
      -  "openalex",
      -  "crossref",
      -  "arxiv",
      -  "biorxiv",
      -  "medrxiv",
      -  "datacite",
      -  "ensembl",
      -  "ucsc",
      -  "biomart",
      -  "mygene",
      -  "gnomad",
      -  "clinvar",
      -  "dbsnp",
      -  "variation",
      -  "cadd",
      -  "gtex",
      -  "eqtlcatalogue",
      -  "gwascatalog",
      -  "pheweb",
      -  "uniprot",
      -  "interpro",
      -  "string",
      -  "proteinatlas",
      -  "alphafold",
      -  "pdb",
      -  "emdb",
      -  "complexportal",
      -  "intact",
      -  "chembl",
      -  "pubchem",
      -  "chebi",
      -  "bindingdb",
      -  "zinc",
      -  "rhea",
      -  "clinicaltrials",
      -  "openfda",
      -  "opentargets",
      -  "civic",
      -  "clingen",
      -  "cosmic",
      -  "depmap",
      -  "cbioportal",
      -  "geo",
      -  "arrayexpress",
      -  "pride",
      -  "metabolights",
      -  "mgnify",
      -  "encode",
      -  "jaspar",
      -  "unibind",
      -  "cellguide",
      -  "panglaodb",
      -  "antibodyregistry",
      -  "ols",
      -  "quickgo",
      -  "reactome",
      -  "kegg",
      -  "rfam",
      -  "grantsgov"
      -]New value: +[
      +  "pubmed",
      +  "pmc-idconv",
      +  "europepmc",
      +  "openalex",
      +  "crossref",
      +  "arxiv",
      +  "biorxiv",
      +  "medrxiv",
      +  "datacite",
      +  "ensembl",
      +  "ucsc",
      +  "biomart",
      +  "mygene",
      +  "ncbi-gene",
      +  "hgnc",
      +  "gnomad",
      +  "clinvar",
      +  "dbsnp",
      +  "variation",
      +  "cadd",
      +  "gtex",
      +  "eqtlcatalogue",
      +  "gwascatalog",
      +  "pheweb",
      +  "uniprot",
      +  "interpro",
      +  "string",
      +  "proteinatlas",
      +  "alphafold",
      +  "pdb",
      +  "emdb",
      +  "complexportal",
      +  "intact",
      +  "chembl",
      +  "pubchem",
      +  "chebi",
      +  "bindingdb",
      +  "zinc",
      +  "rhea",
      +  "clinicaltrials",
      +  "openfda",
      +  "opentargets",
      +  "civic",
      +  "clingen",
      +  "cosmic",
      +  "depmap",
      +  "cbioportal",
      +  "geo",
      +  "arrayexpress",
      +  "pride",
      +  "metabolights",
      +  "mgnify",
      +  "encode",
      +  "jaspar",
      +  "unibind",
      +  "cellguide",
      +  "panglaodb",
      +  "antibodyregistry",
      +  "ols",
      +  "quickgo",
      +  "identifiers-org",
      +  "ncbi-taxonomy",
      +  "reactome",
      +  "kegg",
      +  "rfam",
      +  "grantsgov"
      +]
  3. First observed

TDQS

B3.1/5.0
Behavior3/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

The annotations already state readOnlyHint=true, openWorldHint=true, and destructiveHint=false, so the safety profile is covered. The description adds some context by saying rows can be handed downstream, implying reusable output, but it does not mention rate limits, authentication, pagination, error behavior, or result shape.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness4/5

Is the description appropriately sized, front-loaded, and free of redundancy?

The description is a single front-loaded sentence with no preamble or filler. The long list of database examples duplicates the authority enum and the approximate '~60' is imprecise, but the sentence remains efficient overall.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness2/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

For a tool with 66 authority values, a nested _subject parameter, and an output schema, the description omits how to choose among authorities and query forms. It also leaves the relationship to the many lookup_* siblings unexplained, which is important routing context.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters3/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

Schema description coverage is 100%, so the schema already documents authority, query, limit, _subject, and _files in detail. The description does not add meaning beyond the schema; its database examples largely repeat values already present in the authority enum.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose4/5

Does the description clearly state what the tool does and how it differs from similar tools?

The description gives a specific verb and resource: 'Ask one of the ~60 authoritative databases a question', and names representative databases such as Ensembl, UniProt, and PubMed. This is clear, but it does not distinguish this generic query tool from the many specialized siblings like lookup_gene, lookup_protein, or lookup_variant.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines2/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

There is no when-to-use or when-not-to-use guidance, and no alternatives are named. Listing databases does not help an agent decide between query_database and the specialized lookup_* tools that cover overlapping resources.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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