Previous value: -"Gene — HGNC symbol (e.g. PCSK9) or Ensembl gene ID (e.g. ENSG00000169174). Obtain a stable ID from ensembl_lookup_gene. Mutually exclusive with transcript_id and region; blank means omitted."New value: +"Gene — HGNC symbol (e.g. PCSK9) or Ensembl gene ID (e.g. ENSG00000169174). Obtain a stable ID from ensembl_lookup_gene. Mitochondrial genes (e.g. MT-TL1) are not served. Mutually exclusive with transcript_id and region; blank means omitted."

Previous value: -[
-  {
-    "const": "",
-    "type": "string"
-  },
-  {
-    "description": "Genomic region chrom-start-stop (1-based inclusive, e.g. 13-32315474-32400266).",
-    "pattern": "^[0-9XYM]+-\\d+-\\d+$",
-    "type": "string"
-  }
-]New value: +[
+  {
+    "const": "",
+    "type": "string"
+  },
+  {
+    "description": "Genomic region chrom-start-stop (1-based inclusive, e.g. 13-32315474-32400266) on chromosome 1–22, X, or Y, optional chr prefix.",
+    "pattern": "^(?:chr)?[0-9A-Z]+-\\d+-\\d+$",
+    "type": "string"
+  }
+]

Previous value: -"Genomic region chrom-start-stop (1-based inclusive). Mutually exclusive with gene and transcript_id."New value: +"Genomic region chrom-start-stop (1-based inclusive, e.g. 13-32315474-32400266): chromosome 1–22, X, or Y with an optional chr prefix (mitochondrial regions are not served), a span (stop − start) under 2,500,000 bp, and at most ~30,000 variants. Mutually exclusive with gene and transcript_id."

Previous value: -"Machine-readable failure mode. Declared by this tool: `invalid_target`: Not exactly one of gene, transcript_id, or region was supplied. `incoherent_build`: reference_genome was supplied but does not match the dataset. Other values are possible when a failure originates below the handler."New value: +"Machine-readable failure mode. Declared by this tool: `invalid_target`: Not exactly one of gene, transcript_id, or region was supplied. `incoherent_build`: reference_genome was supplied but does not match the dataset. `invalid_region`: The region names a chromosome outside 1–22, X, Y, or breaks the coordinate bounds. `region_too_large`: The region spans 2,500,000 bp or more, or holds more variants (~30,000) than gnomAD lists at once. `mitochondrial_unsupported`: The gene, transcript, or region is on the mitochondrial chromosome (M or MT). `graphql_error`: gnomAD rejected the variant-list query with a GraphQL error. `upstream_unavailable`: gnomAD stayed unavailable or throttled through every retry. `upstream_timeout`: Every attempt to reach gnomAD timed out. `upstream_access`: gnomAD refused the request (access denied). `invalid_upstream_response`: gnomAD kept answering with a response that failed validation. Other values are possible when a failure originates below the handler."

Previous value: -[
-  "invalid_target",
-  "incoherent_build"
-]New value: +[
+  "invalid_target",
+  "incoherent_build",
+  "invalid_region",
+  "region_too_large",
+  "mitochondrial_unsupported",
+  "graphql_error",
+  "upstream_unavailable",
+  "upstream_timeout",
+  "upstream_access",
+  "invalid_upstream_response"
+]

Previous value: -"Optional canvas ID from a prior call, to reuse the same canvas. Reusing it REPLACES (overwrites) the gene_variants table with this call's results — it does not append. Omit to start a fresh canvas; the response returns a new one."New value: +"Optional canvas ID from a prior call, to reuse the same canvas. When supplied, this call always writes its result to the gene_variants table on that canvas, replacing (not appending to) the previous one — even when the result fits inline; a result with no variants removes the table. Omit to stage on a fresh canvas only when the result is too large to inline."

Added value: +[
+  {
+    "description": "Gene — HGNC symbol (e.g. PCSK9) or Ensembl gene ID (e.g. ENSG00000169174). Obtain a stable ID from ensembl_lookup_gene.",
+    "minLength": 2,
+    "type": "string"
+  },
+  {
+    "description": "Blank — the gene is treated as omitted.",
+    "maxLength": 0,
+    "type": "string"
+  }
+]

Previous value: -"Gene — HGNC symbol (e.g. PCSK9) or Ensembl gene ID (e.g. ENSG00000169174). Obtain a stable ID from ensembl_lookup_gene."New value: +"Gene — HGNC symbol (e.g. PCSK9) or Ensembl gene ID (e.g. ENSG00000169174). Obtain a stable ID from ensembl_lookup_gene. Mutually exclusive with transcript_id and region; blank means omitted."

Removed value: -2

Removed value: -"string"

Previous value: -"Ensembl transcript ID (e.g. ENST00000302118). Mutually exclusive with gene and region."New value: +"Ensembl transcript ID (e.g. ENST00000302118). Mutually exclusive with gene and region; blank means omitted."

Previous value: -"Canvas ID — pass to gnomad_dataframe_query. Empty string when canvas is disabled."New value: +"Canvas holding table_name (or the canvas_id you supplied) — pass it to gnomad_dataframe_describe, then gnomad_dataframe_query. Empty when this call used no canvas: the result fit inline and no canvas_id was supplied, or the canvas is disabled."

Previous value: -"Guidance when no variants matched, or when the canvas is disabled and the preview is capped."New value: +"Guidance when no variants matched, when the canvas is disabled and the preview is capped, and — when a table was staged — its name with the next steps: gnomad_dataframe_describe, then gnomad_dataframe_query."

Previous value: -"Inline preview rows — the immediate answer."New value: +"Inline preview rows — the immediate answer; every matching variant unless spilled."

Previous value: -"True when the full result was staged on the canvas beyond the preview."New value: +"True when the result exceeded the inline preview budget, so the preview holds only the first rows and table_name holds them all."

Previous value: -"Canvas table holding the full set (gene_variants); empty when not spilled."New value: +"Canvas table this call staged (gene_variants), holding every matching variant — inspect it with gnomad_dataframe_describe, then query it with gnomad_dataframe_query. Empty when this call staged no table."

Previous value: -"Total matching variants (staged row count when spilled, else preview length)."New value: +"Total matching variants, including any beyond the preview."

Added value: +"^[A-Za-z0-9_-]{10}$"

Removed value: -[
-  {
-    "type": "number"
-  },
-  {
-    "type": "null"
-  }
-]

Added value: +[
+  "number",
+  "null"
+]

Removed value: -[
-  {
-    "type": "string"
-  },
-  {
-    "type": "null"
-  }
-]

Added value: +[
+  "string",
+  "null"
+]