Added value: +{
+  "description": "Reference and alternate alleles returned by VEP, separated by slashes.",
+  "type": "string"
+}

Previous value: -"Clinical significance terms from ClinVar (e.g. pathogenic, benign)."New value: +"Aggregate clinical significance terms for the colocated record; these do not classify the submitted allele."

Added value: +{
+  "additionalProperties": {
+    "items": {
+      "type": "string"
+    },
+    "type": "array"
+  },
+  "description": "Clinical significance terms keyed by the allele explicitly annotated in the colocated record. Missing alleles have no reported attribution.",
+  "propertyNames": {
+    "type": "string"
+  },
+  "type": "object"
+}

Added value: +{
+  "description": "Reference allele for the colocated clinical annotations, when reported.",
+  "type": "string"
+}

Previous value: -"Per-transcript consequence details, capped to max_transcript_consequences. High-impact variants may affect many transcripts; focus on canonical transcripts (isCanonical from ensembl_lookup_gene) for primary effect. transcriptConsequencesTotal reports the full count."New value: +"Per-transcript consequence details, capped to max_transcript_consequences. High-impact variants may affect many transcripts; canonical and maneSelect identify annotated primary transcripts. transcriptConsequencesTotal reports the full count."

Added value: +{
+  "description": "Whether Ensembl marks this consequence transcript as canonical. Omitted when not reported.",
+  "type": "boolean"
+}

Added value: +{
+  "description": "MANE Select RefSeq transcript accession, when supplied.",
+  "type": "string"
+}

Added value: +{
+  "description": "Allele this transcript consequence describes, in the upstream genomic orientation.",
+  "type": "string"
+}

Previous value: -"Species in Ensembl internal format. Default is homo_sapiens. For non-human variants, set the appropriate species (e.g. mus_musculus for mouse). Use ensembl_list_species to discover valid values."New value: +"Species in Ensembl internal format. Default is homo_sapiens. For non-human variants, set the appropriate species (e.g. mus_musculus for mouse). Use ensembl_list_species with nameContains (a genus or common name) to find valid values."

Previous value: -"Machine-readable failure mode. Declared by this tool: `invalid_notation`: The variant notation is malformed or cannot be parsed by VEP. `not_found`: The variant location falls outside any known transcript or assembly region. Other values are possible when a failure originates below the handler."New value: +"Machine-readable failure mode. Declared by this tool: `invalid_notation`: The variant notation is malformed or cannot be parsed by VEP. `not_found`: The variant location falls outside any known transcript or assembly region. `invalid_species`: The species string was not recognized by Ensembl. Other values are possible when a failure originates below the handler."

Previous value: -[
-  "invalid_notation",
-  "not_found"
-]New value: +[
+  "invalid_notation",
+  "not_found",
+  "invalid_species"
+]

Added value: +1

Added value: +1

Previous value: -"http://json-schema.org/draft-07/schema#"New value: +"https://json-schema.org/draft/2020-12/schema"

Added value: +false

Previous value: -"http://json-schema.org/draft-07/schema#"New value: +"https://json-schema.org/draft/2020-12/schema"

Added value: +[
+  {
+    "not": {
+      "required": [
+        "error"
+      ]
+    },
+    "required": [
+      "results",
+      "totalCount"
+    ]
+  },
+  {
+    "required": [
+      "error"
+    ]
+  }
+]

Added value: +{
+  "additionalProperties": {},
+  "description": "Present when the call failed. Absent on success.",
+  "properties": {
+    "code": {
+      "description": "JSON-RPC error code for this failure.",
+      "maximum": 9007199254740991,
+      "minimum": -9007199254740991,
+      "type": "integer"
+    },
+    "data": {
+      "additionalProperties": {},
+      "properties": {
+        "reason": {
+          "description": "Machine-readable failure mode. Declared by this tool: `invalid_notation`: The variant notation is malformed or cannot be parsed by VEP. `not_found`: The variant location falls outside any known transcript or assembly region. Other values are possible when a failure originates below the handler.",
+          "examples": [
+            "invalid_notation",
+            "not_found"
+          ],
+          "type": "string"
+        },
+        "recovery": {
+          "additionalProperties": {},
+          "description": "Actionable next step for the caller.",
+          "properties": {
+            "hint": {
+              "type": "string"
+            }
+          },
+          "required": [
+            "hint"
+          ],
+          "type": "object"
+        },
+        "retryable": {
+          "description": "Whether retrying may succeed.",
+          "type": "boolean"
+        }
+      },
+      "type": "object"
+    },
+    "message": {
+      "description": "Human-readable description of what went wrong.",
+      "type": "string"
+    }
+  },
+  "required": [
+    "code",
+    "message"
+  ],
+  "type": "object"
+}

Removed value: -[
-  "results",
-  "totalCount"
-]

Added value: +{
+  "default": false,
+  "description": "When true, return every PubMed ID for each colocated variant, overriding max_pubmed_ids_per_variant. Default false to keep responses compact.",
+  "type": "boolean"
+}

Added value: +{
+  "default": 10,
+  "description": "Maximum PubMed IDs to return per colocated known variant. Well-studied variants (e.g. rs334) cite 100+ papers; the default trims each list. Set to 0 to return every PubMed ID uncapped. pubmedTotal on each colocated variant reports the true pre-cap count. Ignored when include_all_colocated_pubmed is true.",
+  "maximum": 9007199254740991,
+  "minimum": 0,
+  "type": "integer"
+}

Added value: +{
+  "default": 10,
+  "description": "Maximum transcript consequences to return per VEP record. High-impact variants can affect 60+ transcripts; the default keeps the response focused on the top consequences. Set to 0 to return every transcript consequence uncapped. transcriptConsequencesTotal on each record always reports the true pre-cap count.",
+  "maximum": 9007199254740991,
+  "minimum": 0,
+  "type": "integer"
+}

Added value: +{
+  "description": "The max_transcript_consequences limit applied.",
+  "type": "number"
+}

Previous value: -"Guidance when no results are returned."New value: +"Guidance when no results are returned or when caps omitted detail."

Previous value: -"PubMed IDs for literature associated with this variant."New value: +"PubMed IDs for literature associated with this variant, capped to max_pubmed_ids_per_variant. pubmedTotal reports the full count when the list was capped."

Added value: +{
+  "description": "Total PubMed IDs available for this variant before the max_pubmed_ids_per_variant cap. Equals the returned pubmed length when the list was not capped.",
+  "type": "number"
+}

Previous value: -"Per-transcript consequence details. High-impact variants may affect many transcripts; focus on canonical transcripts (isCanonical from ensembl_lookup_gene) for primary effect."New value: +"Per-transcript consequence details, capped to max_transcript_consequences. High-impact variants may affect many transcripts; focus on canonical transcripts (isCanonical from ensembl_lookup_gene) for primary effect. transcriptConsequencesTotal reports the full count."

Added value: +{
+  "description": "Total transcript consequences available before the max_transcript_consequences cap. Equals the returned transcriptConsequences length when not capped.",
+  "type": "number"
+}

Added value: +{
+  "description": "Total transcript consequences returned across all records after the cap.",
+  "type": "number"
+}

Added value: +{
+  "description": "True when transcript consequences were capped at max_transcript_consequences.",
+  "type": "boolean"
+}

Previous value: -"Variant in one of two formats: (1) HGVS notation — transcript-relative: ENST00000380152.8:c.2T>A; genomic: 13:g.32316462T>A; (2) Region+allele: chr:start:end:strand/allele — e.g. 1:65568:65568:1/T. For region+allele, strand is 1 (forward) or -1 (reverse); chromosome names use no \"chr\" prefix for vertebrates."New value: +"Variant in one of three formats: (1) HGVS notation — transcript-relative: ENST00000380152.8:c.2T>A; genomic: 13:g.32316462T>A; (2) Region+allele: chr:start:end:strand/allele — e.g. 1:65568:65568:1/T (strand is 1 for forward or -1 for reverse); (3) dbSNP rsID — e.g. rs334. Ensembl normalizes chromosome names; canonical vertebrate output omits the \"chr\" prefix, though a chr-prefixed name is also accepted."