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get_target_profile

Read-only

PROFILE A DRUG TARGET: tractability by modality, genetic constraint, safety liabilities, essentiality, chemical probes, location, interaction partners and the AlphaFold predicted structure (pLDDT, PDB/CIF links). NEXT: get_expression for where it is expressed, search_compounds or find_repurposing_leads for molecules.

Input Schema

NameRequiredDescriptionDefault
symbolYesHGNC symbol or ENSG id.

Output Schema

NameRequiredDescriptionDefault
dataNoThe answer. Shape depends on the tool; describe_tool documents it.
_metaNosource, generatedAt, sources (per-source lastSyncedAt and ageHours), rateLimit, disclaimer.

Schema Changelog

Changes observed during successful MCP inspections.

  1. Changed1 schema field changed
    • changedOutput schema / (root)
      Previous value: -nullNew value: +{
      +  "$schema": "http://json-schema.org/draft-07/schema#",
      +  "additionalProperties": {},
      +  "properties": {
      +    "_meta": {
      +      "additionalProperties": {},
      +      "description": "source, generatedAt, sources (per-source lastSyncedAt and ageHours), rateLimit, disclaimer.",
      +      "propertyNames": {
      +        "type": "string"
      +      },
      +      "type": "object"
      +    },
      +    "data": {
      +      "description": "The answer. Shape depends on the tool; describe_tool documents it."
      +    }
      +  },
      +  "type": "object"
      +}
  2. Changed1 schema field changed
    • addedInput schema / properties / symbol / maxLength
      Added value: +20000
  3. Added

TDQS

A4.3/5.0
Behavior4/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

Annotations already declare readOnlyHint and openWorldHint, so the safety profile is covered. The description adds substantive content context — what data types are returned (pLDDT scores, PDB/CIF links) — which goes beyond the annotations. Minor gap on freshness/rate behavior.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness5/5

Is the description appropriately sized, front-loaded, and free of redundancy?

Two dense sentences with the resource and content list front-loaded, followed by a compact routing clause. No wasted words.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness5/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

With an output schema present, return values needn't be fully explained, yet the description still signals the profile's content areas and the natural next steps. Sufficient for an agent to call correctly with the right follow-ups.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters3/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

Schema coverage is 100% and the single parameter is documented as 'HGNC symbol or ENSG id.' The description adds nothing about the symbol parameter, so baseline 3 is appropriate since the schema carries the load.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose5/5

Does the description clearly state what the tool does and how it differs from similar tools?

States a specific verb+resource ('PROFILE A DRUG TARGET') and enumerates the profile's contents — tractability, genetic constraint, safety liabilities, essentiality, chemical probes, location, interactions, AlphaFold structure. This is clearly distinguishable from siblings like get_target_evidence or get_gene.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines4/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

The 'NEXT' clause explicitly routes the agent to get_expression for expression and search_compounds/find_repurposing_leads for molecules, giving clear follow-on guidance. It stops short of stating when NOT to use this tool or contrasting with get_target_evidence directly.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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