nullary

search_failed_vaccines

Read-onlyIdempotent

Failed/terminated vaccines (by pathogen/indication).

Input Schema

TableJSON Schema

Name	Required	Description	Default
`tier`	No	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).	curated
`limit`	No	Maximum number of findings to return (1–100, default 25).
`offset`	No	Number of findings to skip before this page, for pagination (default 0).
`target`	No	UniProt accession or gene symbol
`outcome`	No	outcome filter (inactive, failed_safety, terminated, …)
`indication`	No	disease/indication

Output Schema

TableJSON Schema

Name	Required	Description
`findings`	No	Matching negative findings (same shape as the REST /findings endpoint).
`has_more`	No	True when more results exist beyond this page.
`coverage_note`	No	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
`query_metadata`	Yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
`returned_count`	No	Findings returned in this page.

Schema Changelog

Changes observed during successful MCP inspections. Dates show when Glama detected each change.

Changed3 schema fields changedMay 25, 2026

addedInput schema / properties / limit / description

Added value: +"Maximum number of findings to return (1–100, default 25)."

addedInput schema / properties / offset / description

Added value: +"Number of findings to skip before this page, for pagination (default 0)."

changedOutput schema / (root)

Previous value: -nullNew value: +{
+  "properties": {
+    "coverage_note": {
+      "description": "Honest coverage caveat for thin Phase-1 modalities (present only when relevant).",
+      "type": "string"
+    },
+    "findings": {
+      "description": "Matching negative findings (same shape as the REST /findings endpoint).",
+      "items": {
+        "type": "object"
+      },
+      "type": "array"
+    },
+    "has_more": {
+      "description": "True when more results exist beyond this page.",
+      "type": "boolean"
+    },
+    "query_metadata": {
+      "description": "Echo of the resolved query — tool, limit, offset, and any applied presets.",
+      "type": "object"
+    },
+    "returned_count": {
+      "description": "Findings returned in this page.",
+      "type": "integer"
+    }
+  },
+  "required": [
+    "query_metadata"
+  ],
+  "type": "object"
+}

First observedMay 25, 2026

TDQS

B3.2/5.0

Behavior3/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

Annotations clearly indicate read-only, open-world, and idempotent behavior, so the safety profile is covered. The description adds no additional behavioral context (e.g., pagination, curated vs all tiers) beyond what annotations and schema already provide, but does not contradict them.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness4/5

Is the description appropriately sized, front-loaded, and free of redundancy?

The description is a single, concise fragment with no wasted words. It fronts the core resource (failed vaccines) and a key filter. However, its brevity borders on underspecification, though for the information it conveys, it is appropriately compact.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness3/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

The rich input schema, annotations, and presence of an output schema compensate for the terse description. However, given the large sibling list and nuanced failure types, the description alone is insufficient to fully contextualize the tool's scope or return semantics, leaving gaps in decision-making.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters3/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

Schema description coverage is 100%, with each parameter well-documented. The description adds only a vague mention of 'pathogen', which is not an actual parameter (it might map to 'target' or 'indication'), and does not clarify the tier or outcome filters beyond what the schema already states.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose4/5

Does the description clearly state what the tool does and how it differs from similar tools?

The description clearly identifies the resource as failed/terminated vaccines and adds a filtering dimension ('by pathogen/indication'), distinguishing it from generic failure searches. However, it lacks an explicit verb, relying on the tool name for 'search', and does not differentiate from siblings like search_vaccine_immunogenicity_failures.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines2/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

The description provides no guidance on when to use this tool versus the many sibling search tools (e.g., search_failed_clinical_antibodies, search_vaccine_immunogenicity_failures). There are no exclusions, prerequisites, or alternative recommendations.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

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