nullary

search_failed_guides

Read-onlyIdempotent

Failed/ineffective CRISPR guides.

Input Schema

TableJSON Schema

Name	Required	Description	Default
`tier`	No	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).	curated
`limit`	No	Maximum number of findings to return (1–100, default 25).
`offset`	No	Number of findings to skip before this page, for pagination (default 0).
`target`	No	UniProt accession or gene symbol
`outcome`	No	outcome filter (inactive, failed_safety, terminated, …)
`compound`	No	compound name, ChEMBL ID, or InChIKey

Output Schema

TableJSON Schema

Name	Required	Description
`findings`	No	Matching negative findings (same shape as the REST /findings endpoint).
`has_more`	No	True when more results exist beyond this page.
`coverage_note`	No	Honest coverage caveat for thin Phase-1 modalities (present only when relevant).
`query_metadata`	Yes	Echo of the resolved query — tool, limit, offset, and any applied presets.
`returned_count`	No	Findings returned in this page.

Schema Changelog

Changes observed during successful MCP inspections. Dates show when Glama detected each change.

Changed3 schema fields changedMay 25, 2026

addedInput schema / properties / limit / description

Added value: +"Maximum number of findings to return (1–100, default 25)."

addedInput schema / properties / offset / description

Added value: +"Number of findings to skip before this page, for pagination (default 0)."

changedOutput schema / (root)

Previous value: -nullNew value: +{
+  "properties": {
+    "coverage_note": {
+      "description": "Honest coverage caveat for thin Phase-1 modalities (present only when relevant).",
+      "type": "string"
+    },
+    "findings": {
+      "description": "Matching negative findings (same shape as the REST /findings endpoint).",
+      "items": {
+        "type": "object"
+      },
+      "type": "array"
+    },
+    "has_more": {
+      "description": "True when more results exist beyond this page.",
+      "type": "boolean"
+    },
+    "query_metadata": {
+      "description": "Echo of the resolved query — tool, limit, offset, and any applied presets.",
+      "type": "object"
+    },
+    "returned_count": {
+      "description": "Findings returned in this page.",
+      "type": "integer"
+    }
+  },
+  "required": [
+    "query_metadata"
+  ],
+  "type": "object"
+}

First observedMay 25, 2026

TDQS

C2.1/5.0

Behavior2/5

Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?

The description discloses no behavioral traits such as pagination, filtering behavior, or return format. With readOnlyHint, openWorldHint, idempotentHint, and destructiveHint already provided in annotations, the description adds no additional context beyond the subject matter, which is more of a purpose detail than a behavioral one.

Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.

Conciseness2/5

Is the description appropriately sized, front-loaded, and free of redundancy?

The description is extremely concise to the point of being a fragment. It lacks a main verb and is not structured as a useful sentence. While there is no wasted text, the extreme under-specification does not earn credit for effective conciseness.

Shorter descriptions cost fewer tokens and are easier for agents to parse. Every sentence should earn its place.

Completeness1/5

Given the tool's complexity, does the description cover enough for an agent to succeed on first attempt?

With 6 parameters, a rich schema, and an output schema, the one-phrase description is wholly inadequate. It does not explain the tool's purpose, use cases, or any context beyond the label, leaving the agent to rely entirely on the name and schema.

Complex tools with many parameters or behaviors need more documentation. Simple tools need less. This dimension scales expectations accordingly.

Parameters3/5

Does the description clarify parameter syntax, constraints, interactions, or defaults beyond what the schema provides?

The description does not mention any parameters. However, schema description coverage is 100% (all 6 parameters have descriptions), so the baseline of 3 applies. The description adds no semantic value beyond the schema.

Input schemas describe structure but not intent. Descriptions should explain non-obvious parameter relationships and valid value ranges.

Purpose2/5

Does the description clearly state what the tool does and how it differs from similar tools?

The description 'Failed/ineffective CRISPR guides.' is a noun phrase without a verb, essentially restating the tool name with added context ('CRISPR'). It does not clearly state that the tool searches for such guides, relying on the name to convey the action. The added 'CRISPR' helps differentiate from sibling tools but does not reach a full sentence.

Agents choose between tools based on descriptions. A clear purpose with a specific verb and resource helps agents select the right tool.

Usage Guidelines2/5

Does the description explain when to use this tool, when not to, or what alternatives exist?

The description provides no guidance on when to use this tool versus alternatives. No alternative tools are named, no exclusions are stated, and the only context is the implicit subject matter.

Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.

All nullary tools Inspect

Try in Browser

RayrunBuild, deploy, and operate MCP servers without becoming an infrastructure team.ray.runAd

Glama MCP Gateway

Add one secure layer between your agents and this server.

Resources

Need Help?