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submit_hydrogen_bond_basicity_workflow

Predict pKBHX values to quantify hydrogen bond acceptance for molecular interactions, solubility, and drug-receptor binding analysis.

Instructions

Submit a hydrogen bond basicity workflow to predict pKBHX values.

Args: initial_molecule: SMILES string representing the molecule do_csearch: Whether to perform conformer search before calculation (default: False) do_optimization: Whether to optimize geometry before calculation (default: False) name: Workflow name for identification and tracking folder_uuid: UUID of folder to organize this workflow. Empty string uses default folder. max_credits: Maximum credits to spend on this calculation. 0 for no limit.

Hydrogen bond basicity (pKBHX) quantifies the ability of a molecule to accept hydrogen bonds, which is important for understanding molecular interactions, solubility, and drug-receptor binding.

Returns: Workflow object representing the submitted workflow

Examples: # Basic hydrogen bond basicity prediction result = submit_hydrogen_bond_basicity_workflow( initial_molecule="CCO", name="Ethanol H-bond basicity" )

# With conformer search and optimization result = submit_hydrogen_bond_basicity_workflow( initial_molecule="c1ccc(cc1)N", do_csearch=True, do_optimization=True, name="Aniline H-bond basicity (optimized)" ) # Predict for a drug molecule result = submit_hydrogen_bond_basicity_workflow( initial_molecule="CN1C=NC2=C1C(=O)N(C(=O)N2C)C", do_csearch=True, name="Caffeine H-bond basicity" )

Input Schema

TableJSON Schema
NameRequiredDescriptionDefault
initial_moleculeYesSMILES string of the molecule for hydrogen bond basicity prediction
do_csearchNoWhether to perform conformer search before calculation
do_optimizationNoWhether to optimize the molecular geometry before calculation
nameNoWorkflow name for identification and trackingHydrogen Bond Basicity Workflow
folder_uuidNoUUID of folder to organize this workflow. Empty string uses default folder
max_creditsNoMaximum credits to spend on this calculation. 0 for no limit

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