Medical Research MCP Suite

import { ClinicalTrialsClient, Study } from '../apis/clinicalTrials.js'; import { FDAClient, FDAAdverseEvent } from '../apis/fda.js'; import { PubMedClient, PubMedPaper } from '../apis/pubmed.js'; import { RiskScoringConfig, DEFAULT_RISK_CONFIG } from '../config/public-interfaces.js'; import { DrugSafetyParams, DrugSafetyProfile, ServiceDependencies as DrugSafetyDeps } from './drugSafety.js'; import { ResearchAnalysisParams, ResearchAnalysisResult, ServiceDependencies as ResearchDeps } from './researchAnalyzer.js'; export class ConfigurableDrugSafetyService { constructor( private dependencies: DrugSafetyDeps, private config: RiskScoringConfig = DEFAULT_RISK_CONFIG ) {} async generateSafetyProfile(params: DrugSafetyParams): Promise<DrugSafetyProfile> { // Use default implementation (private modules disabled) return this.generateWithDefaultAnalyzer(params); } private async generateWithProprietaryAnalyzer(params: DrugSafetyParams, analyzer: any): Promise<DrugSafetyProfile> { const { drugName, includeTrials = true, includeFDA = true, timeframe = '5years' } = params; let clinicalTrialSafety; let fdaSafetyData; if (includeTrials) { clinicalTrialSafety = await this.analyzeClinicalTrialSafety(drugName); } if (includeFDA) { fdaSafetyData = await this.analyzeFDASafetyData(drugName, timeframe); } const comparativeAnalysis = analyzer.generateComparativeAnalysis(clinicalTrialSafety, fdaSafetyData); const overallRiskLevel = analyzer.assessOverallRisk(clinicalTrialSafety, fdaSafetyData); const recommendations = analyzer.generateSafetyRecommendations(clinicalTrialSafety, fdaSafetyData, overallRiskLevel); return { drugName, overallRiskLevel, clinicalTrialSafety, fdaSafetyData, comparativeAnalysis, recommendations, lastUpdated: new Date().toISOString(), }; } private async generateWithDefaultAnalyzer(params: DrugSafetyParams): Promise<DrugSafetyProfile> { const { drugName } = params; return { drugName, overallRiskLevel: 'Unknown', comparativeAnalysis: { clinicalVsRealWorld: 'Analysis unavailable - using default configuration', riskBenefitAssessment: 'Default risk assessment applied', populationSpecificRisks: [], }, recommendations: { monitoringRecommendations: ['Follow standard monitoring guidelines'], contraindicationAlerts: [], doseAdjustmentConsiderations: [], }, lastUpdated: new Date().toISOString(), }; } private async analyzeClinicalTrialSafety(drugName: string) { const searchResult = await this.dependencies.clinicalTrials.searchStudies({ query: { intervention: drugName }, pageSize: 100, }); const studies = searchResult.studies; const completedStudies = studies.filter(study => study.protocolSection.statusModule.overallStatus === 'COMPLETED' ); return { totalStudies: studies.length, completedStudies: completedStudies.length, phasesAnalyzed: ['PHASE1', 'PHASE2', 'PHASE3'], commonSideEffects: ['Nausea', 'Headache', 'Fatigue'], seriousAdverseEvents: ['Severe allergic reaction'], discontinuationRate: studies.length > 0 ? Math.round((1 - completedStudies.length / studies.length) * 100) : 0, }; } private async analyzeFDASafetyData(drugName: string, timeframe: string) { const dateRange = this.calculateDateRange(timeframe); const adverseEventResult = await this.dependencies.fda.getAdverseEvents({ drugName, dateRange, limit: 1000, }); return { totalReports: adverseEventResult.totalCount, seriousReports: adverseEventResult.summary.serious, fatalReports: adverseEventResult.summary.deaths, hospitalizationReports: adverseEventResult.summary.hospitalizations, mostCommonEvents: adverseEventResult.summary.topEvents.map(event => ({ event: event.event, count: event.count, percentage: adverseEventResult.totalCount > 0 ? (event.count / adverseEventResult.totalCount) * 100 : 0, })), ageGroupAnalysis: { 'Adult (18-64)': 50, 'Elderly (65+)': 30, 'Unknown': 20 }, genderAnalysis: { 'Male': 40, 'Female': 45, 'Unknown': 15 }, }; } private calculateDateRange(timeframe: string): { from: string; to: string } { const now = new Date(); const to = now.toISOString().split('T')[0]; let yearsBack = 5; switch (timeframe) { case '1year': yearsBack = 1; break; case '2years': yearsBack = 2; break; case '5years': yearsBack = 5; break; case 'all': yearsBack = 20; break; } const fromDate = new Date(now.getFullYear() - yearsBack, now.getMonth(), now.getDate()); const from = fromDate.toISOString().split('T')[0]; return { from, to }; } }