Medical Research MCP Suite

export interface PublicRiskThresholds { clinicalTrial: { discontinuationRate: number; seriousAdverseEventsCount: number; completionRateThreshold: number; }; fda: { fatalityRateThreshold: number; seriousEventRateThreshold: number; hospitalizationRateThreshold: number; }; comparative: { realWorldClinicalRatio: number; alignmentThreshold: number; }; population: { elderlyAgeThreshold: number; femaleRiskMultiplier: number; }; riskScoring: { highRiskThreshold: number; mediumRiskThreshold: number; strengthDevelopmentThreshold: number; publicationRecencyYears: number; }; } export interface PublicScoringWeights { discontinuationWeight: number; seriousEventsWeight: number; fatalityWeight: number; hospitalizationWeight: number; limitedDataPenalty: number; incompletionPenalty: number; noPhase3Penalty: number; noApprovalPenalty: number; } export interface RiskScoringConfig { thresholds: PublicRiskThresholds; weights: PublicScoringWeights; } export const DEFAULT_RISK_CONFIG: RiskScoringConfig = { thresholds: { clinicalTrial: { discontinuationRate: 0.25, seriousAdverseEventsCount: 5, completionRateThreshold: 0.6, }, fda: { fatalityRateThreshold: 0.02, seriousEventRateThreshold: 0.15, hospitalizationRateThreshold: 0.08, }, comparative: { realWorldClinicalRatio: 2.0, alignmentThreshold: 0.4, }, population: { elderlyAgeThreshold: 70, femaleRiskMultiplier: 1.3, }, riskScoring: { highRiskThreshold: 4, mediumRiskThreshold: 2, strengthDevelopmentThreshold: 0.6, publicationRecencyYears: 3, }, }, weights: { discontinuationWeight: 1, seriousEventsWeight: 1, fatalityWeight: 1, hospitalizationWeight: 1, limitedDataPenalty: 1, incompletionPenalty: 1, noPhase3Penalty: 1, noApprovalPenalty: 1, }, };