Epic Patient API MCP Server

SPRINGFIELD PATHOLOGY ASSOCIATES Surgical Pathology Report Patient: Robert Chen MRN: MRN003 Date of Procedure: January 15, 2024 Date of Report: January 18, 2024 Specimen: Colon biopsy, sigmoid CLINICAL HISTORY: 56-year-old male with rectal bleeding, change in bowel habits, and sigmoid mass seen on colonoscopy. GROSS DESCRIPTION: Received in formalin labeled "sigmoid colon biopsy" are six fragments of tan-pink tissue ranging from 0.2 to 0.4 cm in greatest dimension. All tissue submitted in two cassettes. MICROSCOPIC DESCRIPTION: Sections show colonic mucosa with an invasive adenocarcinoma. The tumor is moderately differentiated and consists of malignant glands infiltrating through the muscularis mucosae into the submucosa. There is associated desmoplastic stromal reaction and lymphovascular space invasion is identified. The malignant glands show enlarged, hyperchromatic nuclei with prominent nucleoli and increased mitotic activity. Areas of necrosis are present. IMMUNOHISTOCHEMISTRY: CK20: Positive CDX2: Positive CK7: Negative MLH1: Retained nuclear expression MSH2: Retained nuclear expression MSH6: Retained nuclear expression PMS2: Retained nuclear expression MOLECULAR: Microsatellite instability testing: Microsatellite stable (MSS) DIAGNOSIS: SIGMOID COLON, BIOPSY: - INVASIVE MODERATELY DIFFERENTIATED ADENOCARCINOMA - LYMPHOVASCULAR INVASION PRESENT - TUMOR IS MICROSATELLITE STABLE COMMENT: This is a conventional colonic adenocarcinoma. Retained expression of mismatch repair proteins (MLH1, MSH2, MSH6, PMS2) indicates microsatellite stable tumor. Clinical correlation and staging studies recommended to determine extent of disease and guide treatment decisions. Pathologist: Dr. Elizabeth Morgan, MD Board Certified Anatomic and Clinical Pathology Date Signed: January 18, 2024