Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?
Annotations already declare readOnlyHint=true, destructiveHint=false, idempotentHint=true. The description adds value by enumerating the exact fields returned (CID, molecular formula, etc.) and emphasizing the database scale (100M+ compounds), which helps the agent understand the tool's scope and output without contradicting annotations.
Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.