Does the description disclose side effects, auth requirements, rate limits, or destructive behavior?
Annotations already declare readOnly, idempotent, non-destructive and closed-world, so the safety profile is covered. The description adds real behavioral value by disclosing the fixed 5-hour half-life assumption that governs the accuracy of the result, plus the shape of the output (remaining mg and clearance forecast). It does not mention that individual variation, smoking, or medication alter clearance, which is the main caveat for this kind of estimate.
Agents need to know what a tool does to the world before calling it. Descriptions should go beyond structured annotations to explain consequences.