Does the description explain when to use this tool, when not to, or what alternatives exist?
Explicitly names what the tool is NOT for (mass, volume, dilution, master mix, LNP formulation, plate map) and routes to the correct alternative ('call that calculator directly'). The sibling list (serial_dilution, pcr_master_mix, plate_map, lnp_formulation, solution_prep) maps cleanly onto those excluded cases, leaving little inference.
Agents often have multiple tools that could apply. Explicit usage guidance like "use X instead of Y when Z" prevents misuse.