input_sensitivity
How far plasma CL moves as each input is varied over a range, e.g. a predicted fu,p over its 50% range.
Input Schema
| Name | Required | Description | Default |
|---|---|---|---|
| rb | No | Blood-to-plasma concentration ratio. fu_b = fu_p / Rb. Output is blood clearance. | |
| fu_p | Yes | Unbound fraction in plasma (0–1). Plasma protein binding correction. | |
| clint | Yes | Intrinsic clearance (µL/min/mg microsomal protein). Use ge=0: zero clearance is physiologically valid. | |
| model | No | IVIVE model. well-stirred (venous equilibrium) or parallel-tube (sinusoidal perfusion). | well-stirred |
| fu_mic | Yes | Unbound fraction in microsomes (0–1). Corrects for non-specific microsomal binding. | |
| species | Yes | Species for physiological parameters (Qh, MPPGL, liver weight). | |
| assay_type | No | Assay type for CLint scaling. microsomes: uses MPPGL (mg/g) × 1e-3; hepatocytes: uses HPGL (×10⁶ cells/g) × 1e-3. | microsomes |
| fu_p_range | No | A predicted fu,p carries its 50% range; pass it to see what it costs. | |
| clint_range | No | ||
| fu_mic_range | No | ||
| correction_id | No | Saved lab correction (/api/correction-equations) to apply. Must match species and assay_type. Corrects predicted plasma CL and replaces the reference band with one from the lab's compounds. | |
| clint_censored | No | Set when the assay reported CLint below its limit of quantification and `clint` is that limit rather than a measurement. CLint then lies in [0, clint), so every clearance output is an upper bound: `upper_bound` is true, no observed-CL band is returned, and the clint_below_loq flag fires. |